Amaechi Bennett Tochukwu, Abdul Azees Parveez Ahamed, Mohseni Sahar, Restrepo-Ceron Maria Camila, Kataoka Yuko, Omosebi Temitope Olabisi, Kanthaiah Kannan
Department of Comprehensive Dentistry, School of Dentistry, University of Texas Health San Antonio, San Antonio, TX 78712, USA.
Department of Odontologia, School of Odontologa, CES University, Medellín 050001, Colombia.
Dent J (Basel). 2024 Sep 12;12(9):290. doi: 10.3390/dj12090290.
This study investigated the efficacy of Isomalt-containing toothpaste in preventing development of dental caries.
Human dental enamel slabs were allocated to six groups (30/group) at random: De-ionized distilled water (DDW), and toothpaste containing 10% Isomalt, 1100 ppm fluoride, 0.05% cetylpyridinium chloride [CPC] (ICT); 10% Isomalt, 1100 ppm fluoride (IT); 10% Isomalt, 1100 ppm fluoride, 1.5% Sodium lauryl sulfate [SLS] (IST); 1100 ppm fluoride only (FT); 1100 ppm fluoride with SLS (FST). The enamel slabs were exposed to caries development via plaque growth in a Microbial Caries Model for 7 days. Toothpastes were applied as slurries (one toothpaste-three DDW) for 2 min twice daily. Demineralization was measured as the change in surface microhardness (ΔSMH) and amount of mineral lost (∆Z), and these metrics were assessed using Transverse Microradiography. Intra-group (SMH) and intergroup (%∆SMH and ∆Z) comparisons were paired -test and Tukey's test (α = 0.05), respectively.
With SMH, demineralization was found to be significant ( < 0.001) in all groups compared to sound enamel baseline, except ICT group. With %ΔSMH, all other groups had significantly ( < 0.001) less demineralization compared to DDW. Significantly ( < 0.001) greater demineralization was observed in IT, FT and FST compared to ICT, and no significant difference was observed between IST and ICT or FT. With ∆Z, relative to the DDW group, the inhibition of demineralization was significant ( < 0.0001) in all groups at varying percentages.
Toothpaste containing 10% Isomalt, 1100 ppm fluoride, and 0.05% CPC demonstrated greater efficacy in inhibiting caries development amid dental plaque compared to toothpaste containing only 1100 ppm fluoride.
本研究调查了含异麦芽酮糖醇牙膏预防龋齿发生的功效。
将人类牙釉质块随机分为六组（每组30个）：去离子蒸馏水（DDW），以及含10%异麦芽酮糖醇、1100 ppm氟化物、0.05%西吡氯铵[CPC]的牙膏（ICT）；10%异麦芽酮糖醇、1100 ppm氟化物（IT）；10%异麦芽酮糖醇、1100 ppm氟化物、1.5%月桂醇硫酸酯钠[SLS]（IST）；仅含1100 ppm氟化物（FT）；含1100 ppm氟化物与SLS（FST）。牙釉质块在微生物龋齿模型中通过菌斑生长暴露于龋齿形成环境7天。牙膏以浆液形式（一种牙膏搭配三份DDW）每天两次涂抹2分钟。脱矿情况通过表面显微硬度变化（ΔSMH）和矿物质流失量（∆Z）来衡量，这些指标使用横向显微放射照相法进行评估。组内（SMH）和组间（%∆SMH和∆Z）比较分别采用配对t检验和Tukey检验（α = 0.05）。
就SMH而言，除ICT组外，所有组与健康牙釉质基线相比脱矿均有显著差异（< 0.001）。就%ΔSMH而言，与DDW相比，所有其他组脱矿均显著减少（< 0.001）。与ICT相比，IT、FT和FST组观察到显著更多脱矿（< 0.001），IST与ICT或FT之间未观察到显著差异。就∆Z而言，相对于DDW组，所有组在不同百分比下脱矿抑制均显著（< 0.0001）。
与仅含1100 ppm氟化物的牙膏相比，含10%异麦芽酮糖醇、1100 ppm氟化物和0.05% CPC的牙膏在抑制牙菌斑中龋齿形成方面显示出更高功效。
