Gliźniewicz Marta, Miłek Dominika, Olszewska Patrycja, Czajkowski Artur, Serwin Natalia, Cecerska-Heryć Elżbieta, Dołęgowska Barbara, Grygorcewicz Bartłomiej
Faculty of Pharmacy, Medical Biotechnology and Laboratory Medicine, Pomeranian Medical University in Szczecin, Szczecin, Poland.
Department of Chemical Technology and Engineering, Institute of Chemical Engineering and Environmental Protection Processes, West Pomeranian University of Technology, Szczecin, Poland.
Front Microbiol. 2024 Jan 5;14:1320345. doi: 10.3389/fmicb.2023.1320345. eCollection 2023.
Bacteria and fungi tend to coexist within biofilms instead of in planktonic states. Usually, such communities include cross-kingdom microorganisms, which make them harder to remove from abiotic surfaces or infection sites. Additionally, the produced biofilm matrix protects embedded microorganisms from antibiotics, disinfectants, or the host immune system. Therefore, classic therapies based on antibiotics might be ineffective, especially when multidrug-resistant bacteria are causative factors. The complexities surrounding the eradication of biofilms from diverse surfaces and the human body have spurred the exploration of alternative therapeutic modalities. Among these options, bacteriophages and their enzymatic counterparts have emerged as promising candidates, either employed independently or in synergy with antibiotics and other agents. Phages are natural bacteria killers because of mechanisms of action that differ from antibiotics, phages might answer worldwide problems with bacterial infections. In this review, we report the attempts to use bacteriophages in combating polymicrobial biofilms in studies, using different models, including the therapeutical use of phages. In addition, we sum up the advantages, disadvantages, and perspectives of phage therapy.
细菌和真菌往往以生物膜的形式共存，而非浮游状态。通常，此类群落包含跨界微生物，这使得它们更难从非生物表面或感染部位清除。此外，产生的生物膜基质可保护其中的微生物免受抗生素、消毒剂或宿主免疫系统的影响。因此，基于抗生素的传统疗法可能无效，尤其是在多重耐药菌为致病因素时。从不同表面和人体根除生物膜的复杂性促使人们探索替代治疗方式。在这些选择中，噬菌体及其酶类对应物已成为有前景的候选者，可单独使用或与抗生素及其他药物协同使用。噬菌体是天然的细菌杀手，由于其作用机制不同于抗生素，噬菌体可能解决全球细菌感染问题。在本综述中，我们报告了在不同模型的研究中使用噬菌体对抗多微生物生物膜的尝试，包括噬菌体的治疗用途。此外，我们总结了噬菌体疗法的优缺点及前景。
