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基因型频率与适合度之间的基本关系。

A fundamental relationship between genotype frequencies and fitnesses.

作者信息

Lachance Joseph

机构信息

Department of Ecology and Evolution, State University of New York, Stony Brook, New York 11794-5222, USA.

出版信息

Genetics. 2008 Oct;180(2):1087-93. doi: 10.1534/genetics.108.093518. Epub 2008 Sep 9.

DOI:10.1534/genetics.108.093518
PMID:18780726
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2567358/
Abstract

The set of possible postselection genotype frequencies in an infinite, randomly mating population is found. Geometric mean heterozygote frequency divided by geometric mean homozygote frequency equals two times the geometric mean heterozygote fitness divided by geometric mean homozygote fitness. The ratio of genotype frequencies provides a measure of genetic variation that is independent of allele frequencies. When this ratio does not equal two, either selection or population structure is present. Within-population HapMap data show population-specific patterns, while pooled data show an excess of homozygotes.

摘要

我们发现了在一个无限大的随机交配群体中可能的选择后基因型频率集合。几何平均杂合子频率除以几何平均纯合子频率等于两倍的几何平均杂合子适合度除以几何平均纯合子适合度。基因型频率的比率提供了一种独立于等位基因频率的遗传变异度量。当这个比率不等于2时，就存在选择或群体结构。群体内的HapMap数据显示了群体特异性模式，而汇总数据则显示纯合子过多。