Leibenguth F
Biochem Genet. 1977 Feb;15(1-2):93-100. doi: 10.1007/BF00484551.
In the natrual populations +Tüb, +Prov, and +Rov, similar AdhF allele frequencies occur (qF = 0.11, 0.18, AND 0.08, respectively). However, there is a discrepancy in that the AdhF allele in +Tüb is closely linked to the lethal factor l(2)Stm, which reduces relative fitness of the F phenotype to zero. In spite of this, polymorphism is maintained also in +Tüb, because the heterozygotes are superior to the homozygous S type (relative fitness = 0.88). Under laboratory culture conditions, in +Tüb the relative fitness of the S genotype further decreases to 0.6. After outcrossing the lethal factor, relative fitnesses for S, FS, and F become 0.6, 1, and 0.48, respectively, implying that fitness for S remains the same. Relative values for S, FS, and F in +Prov, not affected by the lethal factor, are calculated by the maximum average fitness method to be 1, 1.2, and 0.2 under the assumption that heterozyglous FS are similarly superior to S as in the natural +Tüb population and all allele frequencies found are stable equilibrium values.
在自然种群+Tüb、+Prov和+Rov中，AdhF等位基因频率相似（分别为qF = 0.11、0.18和0.08）。然而，存在差异的是，+Tüb中的AdhF等位基因与致死因子l(2)Stm紧密连锁，这使得F表型的相对适合度降至零。尽管如此，+Tüb中仍维持着多态性，因为杂合子优于纯合S型（相对适合度 = 0.88）。在实验室培养条件下，+Tüb中S基因型的相对适合度进一步降至0.6。在将致死因子杂交出去后，S、FS和F的相对适合度分别变为0.6、1和0.48，这意味着S的适合度保持不变。在+Prov中，不受致死因子影响，假设杂合子FS与自然+Tüb种群中的S同样优越且所有发现的等位基因频率均为稳定平衡值，通过最大平均适合度法计算出S、FS和F 的相对值分别为1、1.2和0.2。
