苏拉明对体外吞噬细胞的作用。
Effects of suramin on phagocytes in vitro.
作者信息
Sipka S, Dankó K, Nagy P, Taskov V, Dénes L, Czirják L, Szegedi G
机构信息
3rd Department of Internal Medicine, University Medical School of Debrecen, Hungary.
出版信息
Ann Hematol. 1991 Jul;63(1):45-8. doi: 10.1007/BF01714961.
In the therapeutically important range (100-200 micrograms/ml), suramin was found to increase the phagocytic activity of human monocytes (measured by the uptake of Saccharomyces cerevisiae and sensitized sheep red blood cells) in vitro. Suramin itself was a chemotactic signal for monocytes and increased the chemiluminescence of neutrophil granulocytes. Suramin seems to act via the ATP-binding P2 receptors of human phagocytes.
在具有治疗意义的浓度范围（100 - 200微克/毫升）内，发现苏拉明可在体外增强人单核细胞的吞噬活性（通过酿酒酵母和致敏绵羊红细胞的摄取来测量）。苏拉明本身是单核细胞的趋化信号，并可增强中性粒细胞的化学发光。苏拉明似乎通过人吞噬细胞的ATP结合P2受体发挥作用。
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