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抑郁症的认知疗法与药物治疗：治疗效果及神经机制

Cognitive therapy versus medication for depression: treatment outcomes and neural mechanisms.

作者信息

DeRubeis Robert J, Siegle Greg J, Hollon Steven D

机构信息

University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA.

出版信息

Nat Rev Neurosci. 2008 Oct;9(10):788-96. doi: 10.1038/nrn2345. Epub 2008 Sep 11.

DOI:10.1038/nrn2345
PMID:18784657
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2748674/
Abstract

Depression is one of the most prevalent and debilitating of the psychiatric disorders. Studies have shown that cognitive therapy is as efficacious as antidepressant medication at treating depression, and it seems to reduce the risk of relapse even after its discontinuation. Cognitive therapy and antidepressant medication probably engage some similar neural mechanisms, as well as mechanisms that are distinctive to each. A precise specification of these mechanisms might one day be used to guide treatment selection and improve outcomes.

摘要

抑郁症是最常见且使人衰弱的精神疾病之一。研究表明，认知疗法在治疗抑郁症方面与抗抑郁药物同样有效，而且即使在停止治疗后，它似乎也能降低复发风险。认知疗法和抗抑郁药物可能涉及一些相似的神经机制，以及各自独特的机制。对这些机制的精确阐述或许有朝一日可用于指导治疗选择并改善治疗效果。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f511/2748674/b5e162875e32/nihms102348f4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f511/2748674/cf0f467d7b5c/nihms102348f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f511/2748674/d379d9b939f2/nihms102348f2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f511/2748674/daaf5e25082b/nihms102348f3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f511/2748674/b5e162875e32/nihms102348f4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f511/2748674/cf0f467d7b5c/nihms102348f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f511/2748674/d379d9b939f2/nihms102348f2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f511/2748674/daaf5e25082b/nihms102348f3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f511/2748674/b5e162875e32/nihms102348f4.jpg

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3
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Cognit Ther Res. 2021 Apr;45(2):343-354. doi: 10.1007/s10608-020-10158-5. Epub 2020 Oct 9.
4
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5
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