Kiesslich Ralf, Goetz Martin, Neurath Markus F
I. Med. Department, Johannes Gutenberg University of Mainz, Germany.
Best Pract Res Clin Gastroenterol. 2008;22(5):883-97. doi: 10.1016/j.bpg.2008.05.003.
Confocal laser endomicroscopy enables in vivo microscopy of the mucosal layer of the GI-tract with subcellular resolution during ongoing endoscopy. Endomicroscopy opens a new door for immediate tissue and vessel analysis. Different types of diseases can be diagnosed with optical surface and subsurface analysis. Analysis of the in vivo microarchitecture can be used for targeting biopsies to relevant areas. Furthermore, subsurface imaging can unmask microscopic diseases - (microscopic colitis) or bacterial infection (Helicobacter pylori), for example. Molecular imaging is becoming feasible, and this will shortly open the door to new indications in gastrointestinal endoscopy. This chapter reviews the currently rapidly expanding clinical data about endomicroscopy and gives a look into future research.
共聚焦激光内镜检查能够在内镜检查过程中以亚细胞分辨率对胃肠道黏膜层进行体内显微镜检查。内镜显微镜检查为即时组织和血管分析打开了一扇新的大门。通过光学表面和亚表面分析可以诊断不同类型的疾病。体内微观结构分析可用于将活检靶向相关区域。此外，亚表面成像可以揭示微观疾病（如微观结肠炎）或细菌感染（如幽门螺杆菌）。分子成像正变得可行，这将很快为胃肠内镜检查带来新的适应症。本章回顾了目前关于内镜显微镜检查迅速扩展的临床数据，并展望了未来的研究。
