Department of General Surgery Geriatrics Oncology and Advanced Technology, Center of Excellence for Technical Innovation in Surgery (ITC), Section of Diagnostic and Therapeutic Endoscopy, School of Medicine and Surgery, University of Naples Federico II, 80131 Naples, Italy.
Gastroenterol Res Pract. 2012;2012:525098. doi: 10.1155/2012/525098. Epub 2012 Mar 5.
Confocal laser endomicroscopy (CLE) is one of several novel methods that provide real-time, high-resolution imaging at a micronscale via endoscopes. CLE and related technologies are often termed "virtual biopsy" as they simulate the images seen in traditional histology. Recently, the use of CLE was reported in the study of colonic mucosa in patients with inflammatory bowel diseases and in particular in patients affected by ulcerative colitis. CLE has the potential to have an important role in management of IBD patients as it can be used to assess the grading of colitis and in detection of microscopic colitis in endoscopically silent segments. Moreover, CLE can be used in surveillance programs especially in high-risk patients. This report aims to evaluate the current data on the application of confocal endomicroscopy in clinical gastroenterology and particularly in the study of colonic mucosa in UC patients.
共聚焦激光内镜检查（CLE）是通过内镜提供实时、高分辨率微米级成像的几种新方法之一。CLE 和相关技术通常被称为“虚拟活检”，因为它们模拟了传统组织学中看到的图像。最近，CLE 在炎症性肠病患者的结肠黏膜研究中，特别是在溃疡性结肠炎患者中得到了应用。CLE 在 IBD 患者的管理中具有重要作用，因为它可用于评估结肠炎的分级，并在镜下无明显病变的部位检测显微镜下结肠炎。此外，CLE 可用于监测方案，特别是高危患者。本报告旨在评估共聚焦内镜在临床胃肠病学中的应用，特别是在 UC 患者结肠黏膜研究中的应用。
