Hoffman A, Goetz M, Vieth M, Galle P R, Neurath M F, Kiesslich R
First Dept of Medicine, Johannes Gutenberg University, Mainz, Germany.
Endoscopy. 2006 Dec;38(12):1275-83. doi: 10.1055/s-2006-944813.
Confocal laser endomicroscopy is a newly introduced endoscopic tool that makes it possible to carry out confocal microscopic examination of the mucosal layer during ongoing endoscopy. Different types of tissue and diseases can be diagnosed immediately, facilitating early diagnosis of gastrointestinal cancer. Analysis of the in vivo microarchitecture is helpful in targeting biopsies to relevant areas. In addition, subsurface imaging can unmask microscopic diseases - (microscopic colitis) or bacterial infection ( HELICOBACTER PYLORI), for example. Molecular imaging is becoming feasible, and this will shortly open the door to new indications in gastrointestinal endoscopy (e.g., in vivo receptor analysis).
共聚焦激光内镜检查是一种新引入的内镜工具，它能够在进行内镜检查时对黏膜层进行共聚焦显微镜检查。可以立即诊断出不同类型的组织和疾病，有助于早期诊断胃肠道癌。对体内微观结构的分析有助于将活检靶向相关区域。此外，表面下成像可以揭示微观疾病，例如微观结肠炎或细菌感染（幽门螺杆菌）。分子成像正变得可行，这不久将为胃肠道内镜检查带来新的适应证（例如体内受体分析）。
