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类风湿关节炎中表皮磷脂酶A2活性升高。

Raised epidermal phospholipase A2 activity in rheumatoid arthritis.

作者信息

Taylor H G, Dawes P T, Ilchyshyn A, Shadforth M F, Ilderton E, Yardley H J

机构信息

Skin Department, North Staffordshire Hospital Centre, Stoke-on-Trent, UK.

出版信息

Clin Exp Rheumatol. 1991 May-Jun;9(3):275-7.

PMID:1879087
Abstract

Epidermal phospholipase A2 (PLA2) in RA patients was significantly higher than in normals (p less than 0.0001) but lower than in psoriatic patients (p less than 0.05). No relationship was observed between PLA2 activity and commonly used measures of rheumatoid disease activity in a cross-sectional study. However, in a longitudinal study change in PLA2 activity correlated strongly with changes in disease activity.

摘要

类风湿关节炎(RA)患者的表皮磷脂酶A2(PLA2)显著高于正常人(p<0.0001),但低于银屑病患者(p<0.05)。在一项横断面研究中,未观察到PLA2活性与类风湿疾病活动常用指标之间的关系。然而,在一项纵向研究中,PLA2活性的变化与疾病活动的变化密切相关。

相似文献

1
Raised epidermal phospholipase A2 activity in rheumatoid arthritis.类风湿关节炎中表皮磷脂酶A2活性升高。
Clin Exp Rheumatol. 1991 May-Jun;9(3):275-7.
2
Serum phospholipase A2 correlates with disease activity in rheumatoid arthritis.血清磷脂酶A2与类风湿关节炎的疾病活动度相关。
J Rheumatol. 1988 Sep;15(9):1351-5.
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Phospholipase A2 activity in sera and synovial fluids in rheumatoid arthritis and osteoarthritis. Its possible role as a proinflammatory enzyme.类风湿性关节炎和骨关节炎患者血清及滑液中的磷脂酶A2活性。其作为促炎酶的可能作用。
J Rheumatol. 1985 Apr;12(2):211-6.
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Epidermal phospholipase A2 activity is raised in the uninvolved skin of psoriasis.银屑病未受累皮肤的表皮磷脂酶A2活性升高。
Br J Dermatol. 1983 Jul;109 Suppl 25:30-5.
5
Modulation of phospholipase A2 activity in extracts of lesion-free psoriatic epidermis by alkaline phosphatase and a protein phosphatase inhibitor.碱性磷酸酶和一种蛋白磷酸酶抑制剂对无病变银屑病表皮提取物中磷脂酶A2活性的调节
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6
Membrane-associated phospholipase A2 detected by a radioimmunoassay is a sensitive marker of inflammation in rheumatoid arthritis.通过放射免疫测定法检测到的膜相关磷脂酶A2是类风湿性关节炎炎症的敏感标志物。
Res Commun Chem Pathol Pharmacol. 1992 Jun;76(3):279-85.
7
Phospholipase A2 activity in peripheral blood cells of rheumatoid arthritis patients treated with methotrexate: a preliminary study.甲氨蝶呤治疗的类风湿关节炎患者外周血细胞中的磷脂酶A2活性:一项初步研究。
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Enzymatic activity and distribution of phospholipase A2 in human cartilage.人软骨中磷脂酶A2的酶活性及分布
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9
Inhibition of normal and psoriatic epidermal phospholipase A2 by picomolar concentrations of recombinant human lipocortin I.皮摩尔浓度的重组人脂皮质素I对正常和银屑病表皮磷脂酶A2的抑制作用。
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Circulating phospholipase A2 activity associated with sepsis and septic shock is indistinguishable from that associated with rheumatoid arthritis.与脓毒症和脓毒性休克相关的循环磷脂酶A2活性与类风湿性关节炎相关的循环磷脂酶A2活性无法区分。
Inflammation. 1991 Oct;15(5):355-67. doi: 10.1007/BF00917352.