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Oxidation of alpha-methyldopa and other catechols by cytochrome P-450-generated superoxide anion: possible mechanism of methyldopa hepatitis.

作者信息

Dybing E, Nelson S D, Mitchell J R, Sasame H A, Gillette J R

出版信息

Mol Pharmacol. 1976 Nov;12(6):911-20.

PMID:187927
Abstract
摘要

相似文献

1
Oxidation of alpha-methyldopa and other catechols by cytochrome P-450-generated superoxide anion: possible mechanism of methyldopa hepatitis.细胞色素P-450生成的超氧阴离子对α-甲基多巴和其他儿茶酚的氧化作用：甲基多巴性肝炎的可能机制。
Mol Pharmacol. 1976 Nov;12(6):911-20.
2
Metabolic activation of methyldopa and other catechols.甲基多巴和其他儿茶酚的代谢活化
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Activation of alpha-methyldopa, paracetamol and furosemide by human liver microsomes.人肝微粒体对α-甲基多巴、对乙酰氨基酚和呋塞米的激活作用。
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Activation of the microsomal glutathione S-transferase by metabolites of alpha-methyldopa.α-甲基多巴代谢产物对微粒体谷胱甘肽S-转移酶的激活作用。
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Superoxide anion: its involvement in carbon disulfide hepatotoxicity in phenobarbital-treated rats.超氧阴离子：其在苯巴比妥处理的大鼠二硫化碳肝毒性中的作用。
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Mechanism of oxidation of N-hydroxyphentermine by superoxide.
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Oxygen consumption and oxyradical production from microsomal reduction of aqueous extracts of cigarette tar.香烟焦油水提取物微粒体还原过程中的耗氧量和氧自由基生成量。
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Cytochrome P450IIE1 metabolism of pyridines: evidence for production of a reactive intermediate which exhibits redox-cycling activity and causes DNA damage.细胞色素P450IIE1对吡啶的代谢作用：生成具有氧化还原循环活性并导致DNA损伤的反应性中间体的证据。
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[Substrate reduction and oxygen activation during microsomal metabolism of quinones].[醌类微粒体代谢过程中的底物还原与氧激活]
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Role of P450IIE1 in the metabolism of 3-hydroxypyridine, a constituent of tobacco smoke: redox cycling and DNA strand scission by the metabolite 2,5-dihydroxypyridine.
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Molecular Idiosyncratic Toxicology of Drugs in the Human Liver Compared with Animals: Basic Considerations.药物在人类肝脏中的分子特异性毒理学与动物比较：基本考虑因素。
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Mechanism of idiosyncratic drug induced liver injury (DILI): unresolved basic issues.特异质性药物性肝损伤（DILI）的机制：尚未解决的基本问题。
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Modeling liver-related adverse effects of drugs using knearest neighbor quantitative structure-activity relationship method.
应用最近邻定量构效关系方法建立药物肝毒性相关的预测模型。
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Br J Clin Pharmacol. 1994 Jul;38(1):9-14. doi: 10.1111/j.1365-2125.1994.tb04315.x.
5
Drug metabolism and liver function after methyldopa withdrawal.甲基多巴停药后的药物代谢与肝功能
Br J Clin Pharmacol. 1980 Aug;10(2):115-9. doi: 10.1111/j.1365-2125.1980.tb01727.x.
6
Monooxygenase activity of human liver in microsomal fractions of needle biopsy specimens.人肝脏针吸活检标本微粒体组分中的单加氧酶活性
Br J Clin Pharmacol. 1980 Jan;9(1):11-9. doi: 10.1111/j.1365-2125.1980.tb04790.x.
7
Inhibition of microsomal oxidation of alcohols and of hydroxyl-radical-scavenging agents by the iron-chelating agent desferrioxamine.铁螯合剂去铁胺对醇类微粒体氧化及羟自由基清除剂的抑制作用。
Biochem J. 1983 Jan 15;210(1):107-13. doi: 10.1042/bj2100107.
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Antibody mediated hepatocyte injury in methyl dopa induced hepatotoxicity.甲基多巴诱导的肝毒性中抗体介导的肝细胞损伤
Gut. 1985 Nov;26(11):1233-9. doi: 10.1136/gut.26.11.1233.
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Effect of oxygen concentration on microsomal oxidation of ethanol and generation of oxygen radicals.氧浓度对乙醇微粒体氧化及氧自由基生成的影响。
Biochem J. 1988 May 1;251(3):787-94. doi: 10.1042/bj2510787.
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Clonidine effects on disposition of xenobiotics in rats: inhibited elimination of flow-limited but not extraction-limited agents.可乐定对大鼠体内外源性物质处置的影响：抑制血流限速型而非摄取限速型药物的消除。
Br J Pharmacol. 1988 May;94(1):97-102. doi: 10.1111/j.1476-5381.1988.tb11503.x.