Rose Rebecca F, Merchant William, Stables Graeme I, Lyon Calum L, Platt Alastair
Department of Dermatology, The General Infirmary at Leeds, Leeds, United Kingdom.
J Am Acad Dermatol. 2008 Oct;59(4):627-32. doi: 10.1016/j.jaad.2008.05.035.
Cutaneous carcinosarcomas are rare biphasic malignant tumors with a malignant epithelial component together with malignant stroma. Five cases treated in the Yorkshire region of England between 2003 and 2006 are presented. The patients were male with an age range from 58 to 84 years. Four lesions occurred on the face and one on the trunk. Each tumor had an epithelial component resembling a typical nodular basal cell carcinoma. The stromal components demonstrated atypical spindle cells and tumor giant cells, undifferentiated stroma, or osteoid formation. All underwent surgical excision and none showed evidence of recurrence (follow-up 3-17 months, one death from unrelated causes). The recent literature concerning the pathogenesis and prognosis of these unusual tumors is reviewed.
皮肤癌肉瘤是一种罕见的双相性恶性肿瘤，具有恶性上皮成分和恶性间质。本文报告了2003年至2006年在英国约克郡地区治疗的5例病例。患者均为男性，年龄在58至84岁之间。4个病变发生在面部，1个发生在躯干。每个肿瘤都有一个类似于典型结节性基底细胞癌的上皮成分。间质成分表现为非典型梭形细胞和肿瘤巨细胞、未分化间质或类骨质形成。所有患者均接受了手术切除，且均无复发迹象（随访3至17个月，1例因无关原因死亡）。本文还综述了有关这些罕见肿瘤的发病机制和预后的最新文献。
