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治疗性腹膜内 32P:分布动态的临床评估

Therapeutic intraperitoneal 32P: a clinical assessment of the dynamics of distribution.

作者信息

Kaplan W D, Zimmerman R E, Bloomer W D, Knapp R C, Adelstein S J

出版信息

Radiology. 1981 Mar;138(3):683-8. doi: 10.1148/radiology.138.3.7465847.

DOI:10.1148/radiology.138.3.7465847
PMID:7465847
Abstract

With an Anger camera for scintigraphic recording of bremsstrahlung radiation from phosphorus-32, the distribution of intraperitoneal colloidal chromic phosphate was followed in patients with gynecologic tumors. Sequential pelvic, abdominal, and thoracic scintiphotos over a three-week period revealed rapid and persistent focal aggregation of the radiocolloid with no change in pelvic or peritoneal radionuclide distribution patterns. Visualization of intrathoracic lymph node uptake did not correlate with the presence of diaphragmatic tumor. This study demonstrates the utility of scintigraphy for monitoring the distribution of intraperitoneal beta emitters and the need for developing alternative methods of administering these therapeutic agents to achieve more uniform patterns of distribution.

摘要

使用一台用于对磷-32的轫致辐射进行闪烁照相记录的Anger相机,对患有妇科肿瘤的患者腹腔内胶体磷酸铬的分布情况进行了跟踪。在三周时间内对盆腔、腹部和胸部进行的连续闪烁照相显示,放射性胶体迅速且持续地出现局灶性聚集,盆腔或腹膜放射性核素分布模式没有变化。胸腔内淋巴结摄取的显像与膈肌肿瘤的存在无关。本研究证明了闪烁照相术在监测腹腔内β发射体分布方面的实用性,以及开发替代给药方法以实现更均匀分布模式的必要性。

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1
Therapeutic intraperitoneal 32P: a clinical assessment of the dynamics of distribution.治疗性腹膜内 32P:分布动态的临床评估
Radiology. 1981 Mar;138(3):683-8. doi: 10.1148/radiology.138.3.7465847.
2
Letter: Loculation as a contraindication to intracavitary 32P-chromic phosphate therapy.信函:局限性作为腔内 32P-磷酸铬治疗的禁忌症。
J Nucl Med. 1976 Feb;17(02):150-1.
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The use of scintigraphic and contrast peritoneography in gynecologic malignancies.闪烁扫描法和造影性腹膜造影术在妇科恶性肿瘤中的应用。
Diagn Gynecol Obstet. 1982 Spring;4(1):75-8.
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Radioactivity in blood and urine following intraperitoneal instillation of chromic phosphate in patients with and without ascites.腹腔内注入磷酸铬后,有腹水和无腹水患者血液及尿液中的放射性。
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Peritoneoscintigraphy in detection of improper placement of peritoneal catheter into bowel lumen prior to chromic phosphate P-32 therapy. A case report.在磷酸铬P-32治疗前,腹膜闪烁显像术用于检测腹膜导管误置入肠腔。病例报告。
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Intraperitoneal chromic phosphate P 32 suspension therapy of malignant peritoneal cytology in endometrial carcinoma.
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