Jorge Jorge Manuel Martins, González-Méijome Jose M, Queirós Antonio, Fernandes Paulo, Parafita Manuel A
Department of Physics (Optometry), School of Sciences, University of Minho, Braga, Portugal.
J Glaucoma. 2008 Sep;17(6):442-8. doi: 10.1097/IJG.0b013e31815f52b8.
To investigate the biomechanical properties of the normal cornea, and correlate them with central and peripheral corneal thickness and age.
Seventy-six right eyes of volunteers were measured with Ocular Response Analyzer (ORA), ICare rebound tonometry and an ultrasound pachymeter at corneal center and at 4 mm from corneal center in the nasal and temporal directions.
ICare readings were significantly correlated with central and peripheral corneal thickness and corneal biomechanical properties. Corneal resistance factor was the biomechanical parameter with the higher correlation with ICare intraocular pressure (IOP) values. ICare tonometry at center and Goldmann equivalent IOP obtained with ORA were significantly higher for thicker than thinner corneas (P<0.05). IOP compensated for corneal properties with the ORA was lower than the remaining IOP values measured in the study. Higher correlation was found between Goldmann equivalent IOP with ORA and ICare IOP values.
IOP values obtained with the rebound tonometer are higher in thicker corneas and are positively correlated with biomechanical corneal parameters, namely corneal resistance factor. Although corneal thickness plays a significant role in rebound tonometry, elastic and viscous properties of the cornea seem to play a significant role in the interaction of the tonometer probe with the ocular surface. However, the mechanism behind this process is presently unknown.
研究正常角膜的生物力学特性，并将其与角膜中央和周边厚度以及年龄相关联。
使用眼反应分析仪（ORA）、ICare回弹眼压计和超声角膜测厚仪对76名志愿者的右眼在角膜中央以及距角膜中央鼻侧和颞侧4mm处进行测量。
ICare读数与角膜中央和周边厚度以及角膜生物力学特性显著相关。角膜阻力因子是与ICare眼压（IOP）值相关性较高的生物力学参数。对于较厚角膜，使用ICare眼压计在中央测量的眼压以及使用ORA获得的Goldmann等效眼压明显高于较薄角膜（P<0.05）。使用ORA校正角膜特性后的眼压低于本研究中测量的其他眼压值。ORA的Goldmann等效眼压与ICare眼压值之间存在较高的相关性。
回弹眼压计在较厚角膜中测得的眼压值更高，且与角膜生物力学参数即角膜阻力因子呈正相关。尽管角膜厚度在回弹眼压测量中起重要作用，但角膜的弹性和粘性特性似乎在眼压计探头与眼表的相互作用中起重要作用。然而，这一过程背后的机制目前尚不清楚。
