Serafino Massimiliano, Villani Edoardo, Lembo Andrea, Rabbiolo Giovanni, Specchia Claudia, Trivedi Rupal H, Nucci Paolo
Department of Clinical Sciences and Community Health, Eye Clinic San Giuseppe Hospital, Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS) Multimedica, University of Milan, Via San Vittore, 12, 20123, Milan, Italy.
Department of Molecular and Translational Medicine, Brescia and IRCCS Multimedica, University of Brescia, Milan, Italy.
Int Ophthalmol. 2020 Jan;40(1):19-29. doi: 10.1007/s10792-019-01143-3. Epub 2019 Jul 16.
To compare intraocular pressure (IOP) measurements obtained with the Perkins applanation tonometer and Icare PRO (ICP) rebound tonometer in anesthetized aphakic or strabismus children. Furthermore, intra-operator correlation and inter-operator correlation have been evaluated, along with the effects of central corneal thickness (CCT) on IOP measurements.
Seventy children undergoing examination under anesthesia with sevoflurane for aphakic patients and for surgery for strabismus were included. IOP have been measured twice immediately after anesthesia induction with both Perkins applanation tonometer (PAT) and ICP in one eye and by two different operators with both devices in the fellow eye. Furthermore, CCT was measured with ultrasound pachymetry Pacline (Optikon). Agreement between the device measurements has been evaluated using Bland-Altman analyses. Repeatability and reproducibility of the device have been evaluated with intraclass correlation coefficient (ICC) with a value > 0.75 associated with excellent reliability. The relationship between IOP and CCT has been evaluated with Spearman's correlation coefficient r and determination coefficient r.
Mean difference in IOP measurements between ICP and PAT was 1.97 mmHg ± 1.23 mmHg (p < 0.05). This difference appeared to be higher in aphakic patients (mean difference 2.15 ± 1.35) than in patients undergoing strabismus surgery (mean difference 1.83 mmHg ± 1.12). Intraclass correlation coefficient (ICC) is used to evaluate repeatability and reproducibility, which are both high for PAT (repeatability 0.96, reproducibility 0.76) compared with ICP (repeatability 0.81, reproducibility 0.70). Correlation coefficient between CCT and IOP is 0.66 for both ICP and PAT.
ICP tends to overestimate IOP compared to PAT. Repeatability and reproducibility are both high for PAT as compared to ICP. A significant correlation between IOP and CCT for both instruments has been demonstrated.
比较在麻醉状态下的无晶状体或斜视儿童中，使用帕金斯压平眼压计和Icare PRO（ICP）回弹眼压计测量的眼压（IOP）。此外，还评估了同一操作人员测量结果的相关性和不同操作人员测量结果的相关性，以及中央角膜厚度（CCT）对眼压测量的影响。
纳入70例接受七氟醚麻醉检查的儿童，其中无晶状体患者和斜视手术患者。在麻醉诱导后立即使用帕金斯压平眼压计（PAT）和ICP在一只眼睛上测量眼压两次，由两名不同的操作人员使用这两种设备在另一只眼睛上测量。此外，使用超声角膜测厚仪Pacline（Optikon）测量CCT。使用Bland-Altman分析评估两种设备测量结果之间的一致性。使用组内相关系数（ICC）评估设备的重复性和再现性，ICC值>0.75表示可靠性极佳。使用Spearman相关系数r和决定系数r评估眼压与CCT之间的关系。
ICP和PAT测量的眼压平均差值为1.97 mmHg±1.23 mmHg（p<0.05）。这种差异在无晶状体患者中（平均差值2.15±1.35）似乎比斜视手术患者中（平均差值1.83 mmHg±1.12）更高。组内相关系数（ICC）用于评估重复性和再现性，与ICP（重复性0.81，再现性0.70）相比，PAT的重复性（0.96）和再现性（0.76）都很高。ICP和PAT的CCT与眼压之间的相关系数均为0.66。
与PAT相比，ICP倾向于高估眼压。与ICP相比，PAT的重复性和再现性都很高。两种仪器的眼压与CCT之间均存在显著相关性。
