Murthy R C, Saxena D K, Gupta S K, Chandra S V
Industrial Toxicology Research Centre, Lucknow, India.
Exp Pathol. 1991;42(2):95-100. doi: 10.1016/s0232-1513(11)80054-x.
Oral lead administration (250 ppm lead acetate through drinking water) to weaning male rats for 70 days resulted in the marked accumulation of this metal in blood and testicular tissue. No marked changes were evident in light microscopy. Ultrastructural changes were revealed in the form of vacuolisation of Sertoli cell cytoplasm and increase in the number and size of lysosomes. Some of the vacuoles contained vesicle like structures. Although there was no impairment of spermatogenesis, the changes in the Sertoli cells may lead to changes in spermatogenesis after chronic exposure.
给断奶雄性大鼠经口给予铅（通过饮用水给予250 ppm醋酸铅）70天，导致这种金属在血液和睾丸组织中显著蓄积。光学显微镜下未发现明显变化。超微结构变化表现为支持细胞胞质空泡化以及溶酶体数量和大小增加。一些空泡含有囊泡样结构。虽然精子发生没有受损，但支持细胞的变化可能在慢性暴露后导致精子发生改变。
