Coe T S, Hamilton P B, Griffiths A M, Hodgson D J, Wahab M A, Tyler C R
Environmental and Molecular Fish Biology Group, University of Exeter, Exeter, UK.
Ecotoxicology. 2009 Jan;18(1):144-50. doi: 10.1007/s10646-008-0267-0. Epub 2008 Sep 16.
There is substantial evidence that genetic variation, at both the level of the individual and population, has a significant effect on behaviour, fitness and response to toxicants. Using DNA microsatellites, we examined the genetic variation in samples of several commonly used laboratory strains of zebrafish, Danio rerio, a model species in toxicological studies. We compared the genetic variation to that found in a sample of wild fish from Bangladesh. Our findings show that the wild fish were significantly more variable than the laboratory strains for several measures of genetic variability, including allelic richness and expected heterozygosity. This lack of variation should be given due consideration for any study which attempts to extrapolate the results of ecotoxicological laboratory tests to wild populations.
有大量证据表明，个体和群体层面的基因变异对行为、适应性以及对毒物的反应都有显著影响。我们使用DNA微卫星技术，研究了几种常用的斑马鱼（Danio rerio）实验室品系样本中的基因变异情况，斑马鱼是毒理学研究中的一种模式物种。我们将这些基因变异与来自孟加拉国的野生鱼类样本中的变异进行了比较。我们的研究结果表明，在包括等位基因丰富度和预期杂合度在内的几种基因变异性指标上，野生鱼类的变异性明显高于实验室品系。对于任何试图将生态毒理学实验室测试结果外推至野生种群的研究，都应充分考虑这种变异的缺乏。
