Ness G C, Pendleton L C
Department of Biochemistry and Molecular Biology, College of Medicine, University of South Florida, Tampa 33612.
FEBS Lett. 1991 Aug 19;288(1-2):21-2. doi: 10.1016/0014-5793(91)80993-d.
Livers from hypophysectomized rats had low levels of glyceraldehyde 3-phosphate dehydrogenase mRNA. Administration of L-triiodothyronine increased these levels over 20-fold. The peak response was seen 72 h after hormone administration. A half-maximal response was obtained with 5 micrograms of T3 per 100 g of body weight. Thus the expression of hepatic glyceraldehyde 3-phosphate dehydrogenase appears to be regulated by thyroid hormone.
垂体切除大鼠的肝脏中，磷酸甘油醛脱氢酶mRNA水平较低。给予L-三碘甲状腺原氨酸后，这些水平增加了20倍以上。激素给药后72小时出现峰值反应。每100克体重给予5微克T3可获得半数最大反应。因此，肝脏磷酸甘油醛脱氢酶的表达似乎受甲状腺激素调节。
