Aberer E, Klade H, Stanek G, Gebhart W
IInd Department of Dermatology, University of Vienna, Austria.
Dermatologica. 1991;182(3):145-54.
Thirty patients with different clinical manifestations of morphea (circumscribed scleroderma) were investigated for serum antibodies against Borrelia burgdorferi determined by ELISA and Western blot analysis. Forty-six percent of the patients were seropositive. Western blots confirmed the ELISA results in 10 of 25 patients (40%), showing a reactivity pattern which can be seen in the course of Lyme borreliosis. In some cases the outcome after antibiotic treatment suggests a direct correlation between the further development of skin lesions and Borrelia infection. Because of these findings we suggest some morphea types to be possibly due to a B. burgdorferi infection.
对30例具有硬斑病（局限性硬皮病）不同临床表现的患者进行了研究，通过酶联免疫吸附测定（ELISA）和蛋白质印迹分析来检测其血清中抗伯氏疏螺旋体的抗体。46%的患者血清呈阳性。蛋白质印迹法在25例患者中的10例（40%）中证实了ELISA结果，显示出在莱姆病病程中可见的反应模式。在某些病例中，抗生素治疗后的结果表明皮肤病变的进一步发展与伯氏疏螺旋体感染之间存在直接关联。基于这些发现，我们认为某些硬斑病类型可能归因于伯氏疏螺旋体感染。
