Dos Santos Elisvânia Freitas, Tsuboi Kathia Hitomi, Palu Beatriz Frolini, Araújo Marina Rachel, Andreollo Nelson Adami, Miyasaka Celio Kenji
FEA, DEPAN, UNICAMP, Sao Paulo, Brazil.
Acta Cir Bras. 2008 Sep-Oct;23(5):401-4. doi: 10.1590/s0102-86502008000500002.
To evaluate the effects of the partial gastrectomy associated to anterior truncal vagotomy in the absorption and metabolism of iron.
Eighteen adults male Wistar rats were submitted to the partial gastrectomy associated to anterior truncal vagotomy (eight animals) and the sham operation (10 animals, control group). The diet consumption and the weight gains of the animals were monitored three times during the week. The animals received supplements of vitamin B12, for the prevention of the megaloblastic anemia, and a formulated experimental diet orally and denominated AIN-93M by 8 weeks. The fecal iron, apparent absorption of the iron, haematocrit, haemoglobin and serum iron were measured after 60 days.
The animals undergoing sham operation presented larger statistical averages (p<0.05) for the diet consumption, weight gains, apparent absorption of iron, haematocrit, haemoglobin and serum iron compared to the gastrectomized group. However, the excretion of iron in feces was larger in the gastrectomized group (+14.3%) (p<0.05) when compared to the control group.
Partial gastrectomy associated to anterior truncal vagotomy showed to be a good experimental model the study of iron metabolism, decreasing the haematocrit, the haemoglobin and the iron absorption, consequently causing anemia.
评估胃部分切除术联合迷走神经干前支切断术对铁吸收和代谢的影响。
将18只成年雄性Wistar大鼠分为两组，一组接受胃部分切除术联合迷走神经干前支切断术（8只动物），另一组接受假手术（10只动物，对照组）。在一周内对动物的饮食摄入量和体重增加情况进行三次监测。动物口服补充维生素B12以预防巨幼细胞贫血，并在8周内口服一种名为AIN-93M的配方实验饮食。60天后测量粪便铁、铁的表观吸收率、血细胞比容、血红蛋白和血清铁。
与胃切除组相比，接受假手术的动物在饮食摄入量、体重增加、铁的表观吸收率、血细胞比容、血红蛋白和血清铁方面的统计平均值更高（p<0.05）。然而，与对照组相比，胃切除组的粪便铁排泄量更高（+14.3%）（p<0.05）。
胃部分切除术联合迷走神经干前支切断术是研究铁代谢的良好实验模型，会降低血细胞比容、血红蛋白和铁吸收，从而导致贫血。
