Sundberg John P, Sundberg Beth A, Schofield Paul
The Jackson Laboratory, 600 Main Street, Bar Harbor, ME 04609-1500, USA.
Mamm Genome. 2008 Jun;19(6):413-9. doi: 10.1007/s00335-008-9123-z. Epub 2008 Sep 17.
The Mouse Disease Information System (MoDIS) is a data capture system for pathology data from laboratory mice designed to support phenotyping studies. The system integrates the mouse anatomy (MA) and mouse pathology (MPATH) ontologies into a Microsoft Access database facilitating the coding of organ, tissue, and disease process to recognized semantic standards. Grading of disease severity provides scores for all lesions that can then be used for quantitative trait locus (QTL) analyses and haplotype association gene mapping. Direct linkage to the Pathbase online database provides reference definitions for disease terms and access to photomicrographic images of similar diagnoses in other mutant mice. MoDIS is an open source and freely available program (http://research.jax.org/faculty/sundberg/index.html). This provides a valuable tool for setting up a mouse pathology phenotyping program.
小鼠疾病信息系统（MoDIS）是一个用于收集实验室小鼠病理学数据的数据采集系统，旨在支持表型研究。该系统将小鼠解剖学（MA）和小鼠病理学（MPATH）本体整合到一个Microsoft Access数据库中，便于按照公认的语义标准对器官、组织和疾病过程进行编码。疾病严重程度分级为所有病变提供分数，然后可用于数量性状位点（QTL）分析和单倍型关联基因图谱绘制。与Pathbase在线数据库的直接链接提供了疾病术语的参考定义，并可访问其他突变小鼠中类似诊断的显微照片图像。MoDIS是一个开源且免费的程序（http://research.jax.org/faculty/sundberg/index.html）。这为建立小鼠病理表型分析程序提供了一个有价值的工具。
