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1
Interleukin-2-induced DNA synthesis and immunoglobulin secretion by resting human tonsillar B cells: effects of protein kinase C activation.白细胞介素-2诱导静息人扁桃体B细胞的DNA合成和免疫球蛋白分泌：蛋白激酶C激活的作用
Immunology. 1991 Jul;73(3):322-6.
2
Selective induction of high levels of IgA synthesis in Peyer's patch B cells by protein kinase C-activating phorbol esters.蛋白激酶C激活剂佛波酯对派尔集合淋巴结B细胞中高水平IgA合成的选择性诱导作用。
J Immunol. 1991 Sep 15;147(6):1752-8.
3
Differential inhibition of interleukin 2- and interleukin 4-mediated human B cell proliferation by ionomycin: a possible regulatory role for apoptosis.离子霉素对白细胞介素2和白细胞介素4介导的人B细胞增殖的差异抑制作用：细胞凋亡的一种可能调节作用
Eur J Immunol. 1991 Oct;21(10):2311-6. doi: 10.1002/eji.1830211004.
4
IL-4 counteracts anti-mu-induced human B cell proliferation: involvement of a cAMP-dependent inhibitory pathway.白细胞介素-4抑制抗μ链抗体诱导的人B细胞增殖：环磷酸腺苷依赖性抑制途径的参与。
Eur Cytokine Netw. 1991 Aug-Sep;2(4):265-72.
5
Modulation of IL-2- and IL-4-dependent human B cell proliferation by cyclic AMP.环磷酸腺苷对白细胞介素-2和白细胞介素-4依赖性人B细胞增殖的调节作用
J Immunol. 1991 Jun 15;146(12):4222-7.
6
Detection of functional platelet-activating factor receptors on human tonsillar B lymphocytes.人扁桃体B淋巴细胞上功能性血小板活化因子受体的检测
J Immunol. 1999 May 1;162(9):5498-505.
7
IL-4 promotes anti-Ig-mediated protein kinase C translocation and reverses phorbol ester-mediated protein kinase C down-regulation in murine B cells.白细胞介素-4促进抗免疫球蛋白介导的蛋白激酶C易位，并逆转佛波酯介导的小鼠B细胞中蛋白激酶C的下调。
J Immunol. 1991 Dec 1;147(11):3831-6.
8
Endogenous IL-6 and IL-10 contribute to the differentiation of CD40-activated human B lymphocytes.内源性白细胞介素-6和白细胞介素-10有助于CD40激活的人B淋巴细胞的分化。
J Immunol. 1995 Mar 15;154(6):2533-44.
9
Toll-like receptor 7-induced naive human B-cell differentiation and immunoglobulin production.Toll样受体7诱导人初始B细胞分化及免疫球蛋白产生。
J Allergy Clin Immunol. 2009 Jan;123(1):224-230.e4. doi: 10.1016/j.jaci.2008.09.018. Epub 2008 Nov 7.
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Induction of competence and progression signals in human T lymphocytes by phorbol esters and calcium ionophores.佛波酯和钙离子载体对人T淋巴细胞中感受态和增殖信号的诱导作用。
J Cell Physiol. 1988 Nov;137(2):329-36. doi: 10.1002/jcp.1041370217.

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Exploring the Pathogenic Role and Therapeutic Implications of Interleukin 2 in Autoimmune Hepatitis.探讨白细胞介素 2 在自身免疫性肝炎中的致病作用和治疗意义。
Dig Dis Sci. 2021 Aug;66(8):2493-2512. doi: 10.1007/s10620-020-06562-2. Epub 2020 Aug 24.
2
Chronic Lymphocytic Leukemia B-Cell Normal Cellular Counterpart: Clues From a Functional Perspective.慢性淋巴细胞白血病 B 细胞正常细胞对应物：从功能角度得到的线索。
Front Immunol. 2018 Apr 4;9:683. doi: 10.3389/fimmu.2018.00683. eCollection 2018.
3
Effect of 12,13-phorbol dibutyrate and ionomycin on defective B cells in common variable immunodeficiency.12,13-二丁酰佛波醇和离子霉素对常见可变免疫缺陷中缺陷B细胞的影响。
Clin Exp Immunol. 1992 Mar;87(3):461-4. doi: 10.1111/j.1365-2249.1992.tb03020.x.

本文引用的文献

1
Stimulation of immunoglobulin secretion in human B lymphocytes as a direct effect of high concentrations of IL 2.高浓度白细胞介素2对人B淋巴细胞免疫球蛋白分泌的直接刺激作用。
J Immunol. 1984 Nov;133(5):2442-5.
2
Forskolin: unique diterpene activator of adenylate cyclase in membranes and in intact cells.福斯高林：膜及完整细胞中独特的腺苷酸环化酶二萜激活剂。
Proc Natl Acad Sci U S A. 1981 Jun;78(6):3363-7. doi: 10.1073/pnas.78.6.3363.
3
Separate signals for human B cell proliferation and differentiation in response to Staphylococcus aureus: evidence for a two-signal model of B cell activation.金黄色葡萄球菌诱导人B细胞增殖和分化的独立信号：B细胞激活双信号模型的证据
J Immunol. 1982 Jul;129(1):97-102.
4
Defective low-density cells of dendritic morphology from the blood of patients with common variable hypogammaglobulinaemia: low immunoglobulin production on stimulation of normal B cells.常见可变型低丙种球蛋白血症患者血液中具有树突状形态的低密度细胞缺陷：正常B细胞受刺激后免疫球蛋白产生减少。
Clin Exp Immunol. 1985 Jul;61(1):189-94.
5
Response of human B cells to different anti-immunoglobulin isotypes: absence of a correlation between early activation events and cell proliferation.人类B细胞对不同抗免疫球蛋白同种型的反应：早期激活事件与细胞增殖之间不存在相关性。
Eur J Immunol. 1987 Dec;17(12):1737-42. doi: 10.1002/eji.1830171209.
6
Regulation of human B lymphocyte activation, proliferation, and differentiation.人类B淋巴细胞激活、增殖和分化的调控。
Adv Immunol. 1987;40:1-59. doi: 10.1016/s0065-2776(08)60237-0.
7
Effect of recombinant IL 2 and gamma-IFN on proliferation and differentiation of human B cells.重组白细胞介素2和γ-干扰素对人B细胞增殖和分化的影响。
J Immunol. 1985 Feb;134(2):959-66.
8
Demonstration that human B cells respond differently to interleukin 2 and B cell differentiation factor based on their stages of maturation.基于人类B细胞的成熟阶段，证明其对白细胞介素2和B细胞分化因子的反应不同。
J Immunol. 1986 Nov 15;137(10):3175-82.
9
IL-2 regulation of tyrosine kinase activity is mediated through the p70-75 beta-subunit of the IL-2 receptor.白细胞介素-2对酪氨酸激酶活性的调节是通过白细胞介素-2受体的p70 - 75β亚基介导的。
J Immunol. 1989 Aug 1;143(3):870-6.
10
B cell function in acquired "common-variable" hypogammaglobulinemia: proliferative responses to lymphokines.获得性“常见变异型”低丙种球蛋白血症中的B细胞功能：对淋巴因子的增殖反应。
Clin Immunol Immunopathol. 1989 May;51(2):196-204. doi: 10.1016/0090-1229(89)90019-6.

白细胞介素-2诱导静息人扁桃体B细胞的DNA合成和免疫球蛋白分泌：蛋白激酶C激活的作用

Interleukin-2-induced DNA synthesis and immunoglobulin secretion by resting human tonsillar B cells: effects of protein kinase C activation.

作者信息

Franz A, Bryant A, Farrant J

机构信息

Immunodeficiency Diseases Research Group, Clinical Research Centre, Harrow, U.K.

出版信息

Immunology. 1991 Jul;73(3):322-6.

PMID:1879879
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1384550/
Abstract

Responses to interleukin-2 (IL-2) of high-density human tonsillar B lymphocytes were examined in 20 microliters hanging drop microcultures. DNA synthesis and secretion of IgM and IgG were induced by IL-2 alone. Activation of calcium-dependent protein kinase C (PKC) with phorbol 12,13-dibutyrate and ionomycin increased IL-2 driven DNA synthesis yet reduced IL-2 driven secretion of IgM and IgG. Forskolin, which increases cAMP, had no effect on the responses to IL-2. Intrinsic IL-6 played no role in IL-2-induced DNA synthesis but was partially responsible for the secretion of immunoglobulin. These data show that pre-activation of the high-density human tonsillar B lymphocyte is not a prerequisite for IL-2-driven responses. They also show an asymmetry between the growth and differentiation induced by IL-2. This is reflected by opposite modulation on activation of PKC and by the role of the autocrine factor, IL-6.

摘要

在20微升悬滴微培养体系中检测了高密度人扁桃体B淋巴细胞对白介素-2（IL-2）的反应。单独的IL-2可诱导DNA合成以及IgM和IgG的分泌。用佛波酯12,13 - 二丁酸酯和离子霉素激活钙依赖性蛋白激酶C（PKC）可增加IL-2驱动的DNA合成，但会减少IL-2驱动的IgM和IgG分泌。可增加cAMP的福斯高林对IL-2诱导的反应没有影响。内源性IL-6在IL-2诱导的DNA合成中不起作用，但部分参与免疫球蛋白的分泌。这些数据表明，高密度人扁桃体B淋巴细胞的预激活不是IL-2驱动反应的先决条件。它们还显示了IL-2诱导的生长和分化之间的不对称性。这通过对PKC激活的相反调节以及自分泌因子IL-6的作用得以体现。