急性缺血性卒中中的促炎和抗炎细胞因子及其与早期神经功能缺损和卒中结局的关系。

Pro-inflammatory and anti-inflammatory cytokines in acute ischemic stroke and their relation to early neurological deficit and stroke outcome.

作者信息

Basic Kes Vanja, Simundic Ana-Maria, Nikolac Nora, Topic Elizabeta, Demarin Vida

机构信息

University Department of Neurology, Sestre milosrdnice University Hospital, Zagreb, Croatia.

出版信息

Clin Biochem. 2008 Nov;41(16-17):1330-4. doi: 10.1016/j.clinbiochem.2008.08.080. Epub 2008 Sep 4.

DOI:10.1016/j.clinbiochem.2008.08.080

PMID:18801351

Abstract

OBJECTIVES

Our aim was to explore (i) the difference in concentration of IL-6, TNF-alpha and IL-10 between acute ischemic stroke patients and control individuals; (ii) the association of plasma cytokine concentration with stroke severity at admission assessed by NIHSS and stroke outcome in 90 days assessed by Barthel index (BI) and modified Rankin scale (mRS).

MATERIALS AND METHODS

Study included 68 stroke patients admitted within 12 h of symptoms onset and 71 controls.

RESULTS

IL-6 was increased in patients relative to controls (P=0.035) and this increase was associated with severe stroke (P=0.007) and worse outcome (P=0.030 and 0.019; assessed by BI and mRS, respectively), whereas IL-10 was decreased (P=0.044) and associated with better outcome (P=0.043). TNF-alpha did not differ between studied groups (P=0.302).

CONCLUSIONS

Increased IL-6 and reduced IL-10 concentrations are present in early stroke period and are associated with a degree of neurological deficit and/or stroke outcome.

摘要

目的

我们的目的是探讨（i）急性缺血性中风患者与对照个体之间白细胞介素-6（IL-6）、肿瘤坏死因子-α（TNF-α）和白细胞介素-10（IL-10）浓度的差异；（ii）血浆细胞因子浓度与入院时通过美国国立卫生研究院卒中量表（NIHSS）评估的中风严重程度以及90天时通过巴氏指数（BI）和改良Rankin量表（mRS）评估的中风结局之间的关联。

材料与方法

研究纳入了68例症状发作后12小时内入院的中风患者和71例对照者。

结果

与对照组相比，患者的IL-6升高（P = 0.035），且这种升高与严重中风相关（P = 0.007）和较差的结局相关（分别通过BI和mRS评估，P = 0.030和0.019），而IL-10降低（P = 0.044）且与较好的结局相关（P = 0.043）。TNF-α在研究组之间无差异（P = 0.302）。