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哺乳动物细胞周期中DNA旋转酶活性的变化。

Variation in DNA swivel enzyme activity during the mammalian cell cycle.

作者信息

Rosenberg B H, Ungers G, Deutsch J F

出版信息

Nucleic Acids Res. 1976 Dec;3(12):3305-11. doi: 10.1093/nar/3.12.3305.

DOI:10.1093/nar/3.12.3305
PMID:188020
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC343175/
Abstract

Synchronized cells of a normal human lymphocytic cell line contain little swiven enzyme activity in G0 and G1 and high activity in Sphase. The level of activity in different growth phase appears to be related to the fraction of the population engaged in DNA replication. No endogenous inhibitor or activator of swiven activity could be demonstrated. The evidence implies that the enzyme may be present only during S phase; it is therefore a possible control factor for replication.

摘要

正常人类淋巴细胞系的同步化细胞在G0期和G1期几乎没有swiven酶活性，而在S期活性较高。不同生长阶段的活性水平似乎与参与DNA复制的细胞群体比例有关。未发现swiven活性的内源性抑制剂或激活剂。证据表明该酶可能仅在S期存在；因此它可能是复制的一个控制因子。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4c33/343175/850c1d1361fa/nar00497-0059-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4c33/343175/850c1d1361fa/nar00497-0059-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4c33/343175/850c1d1361fa/nar00497-0059-a.jpg

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本文引用的文献

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