Marchetti Federico, Assael Barouk, Gabutti Giovanni, Guarino Alfredo, Lopalco Pier Luigi, Marocco Alessia, Ruggeri Franco, Titone Lucina, Tozzi Alberto, Rosati Giovanni Vitali, Zotti Carla, Franco Elisabetta
Medical Department, GlaxoSmithKline S.p.A, Verona, Italy.
Hum Vaccin. 2009 Mar;5(3):172-6. doi: 10.4161/hv.5.3.6764. Epub 2009 Mar 10.
Recently, two Rotavirus (RV) vaccines were licensed in Italy, rendering RV illness a vaccine preventable disease. To assess the RV hospitalization rate in Italy, a study focused on the Regional hospital discharge forms (HDD) databases was carried out.
Regional HDD databases from Piemonte, Veneto, Friuli-Venezia-Giulia and Marche were analyzed. A total of 434,335 hospitalizations were counted in the study timeframe and 13,234 VE diagnoses (3% of hospitalizations) were collected. A total of 8546 RVE cases (2% of hospitalizations, 64% of all VE) were observed, of which 1.2% were primary diagnoses (PD) and 0.8% secondary diagnosis (SD). The RVE hospitalization peak (4.9%) was observed at the age of 1 year (4.5% in 7-12 months of age) with a median hospital stay of 4.4 days (s.d +/- 4.2). Two deaths (out of 8546 RVE cases) were identified.
Regional HDD databases with the diagnosis of viral enteritis (VE) and RV enteritis (RVE) (ICD9-CM code 00861-69 and 008.8) in any position of the first 20 discharge diagnoses in children aged less or equal to 5 years between 2001 and 2005 were requested.
Despite some limitations due to the HDD synthetic contents and low potential for clinical interpretation, the Regional HDD databases, including PD and SD, may be a useful tool for monitoring the clinical impact of RV vaccination introduction in Italy.
最近，两种轮状病毒（RV）疫苗在意大利获得许可，使RV疾病成为一种可通过疫苗预防的疾病。为评估意大利的RV住院率，开展了一项针对地区医院出院表格（HDD）数据库的研究。
对皮埃蒙特、威尼托、弗留利-威尼斯朱利亚和马尔凯地区的HDD数据库进行了分析。在研究时间段内共统计到434335例住院病例，并收集到13234例VE诊断病例（占住院病例的3%）。共观察到8546例RVE病例（占住院病例的2%，占所有VE病例的64%），其中1.2%为主要诊断（PD），0.8%为次要诊断（SD）。RVE住院高峰（4.9%）出现在1岁时（7至12个月龄时为4.5%），中位住院时间为4.4天（标准差±4.2）。在8546例RVE病例中发现了2例死亡病例。
要求提供2001年至2005年间5岁及以下儿童前20项出院诊断中任何位置有病毒性肠炎（VE）和RV肠炎（RVE）诊断（ICD9-CM代码00861-69和008.8）的地区HDD数据库。
尽管由于HDD内容综合且临床解读潜力较低存在一些局限性，但包括PD和SD的地区HDD数据库可能是监测意大利引入RV疫苗的临床影响的有用工具。
