Wu Li
Department of Microbiology and Molecular Genetics, Medical College of Wisconsin, Milwaukee, WI 53226, USA.
Curr Opin HIV AIDS. 2008 Sep;3(5):534-40. doi: 10.1097/COH.0b013e32830634c6.
HIV-1 mucosal transmission plays a critical role in HIV-1 infection and AIDS pathogenesis. This review summarizes the latest advances in biological studies of HIV-1 mucosal transmission, highlighting the implications of these studies in the development of microbicides to prevent HIV-1 transmission.
New studies of initial HIV-1 infection using improved culture models updated the current view of mucosal transmission. Mechanistic studies enhanced our understanding of cell-cell transmission of HIV-1 mediated by the major target cells, including dendritic cells, CD4(+) T cells, and macrophages. Increasing evidence indicated the significance of host factors and immune responses in HIV-1 mucosal infection and transmission.
Recent progress in HIV-1 mucosal infection and transmission enriches our knowledge of virus-host interactions and viral pathogenesis. Functional studies of HIV-1 interactions with host cells can provide new insights into the design of more effective approaches to combat HIV-1 infection and AIDS.
HIV-1黏膜传播在HIV-1感染和艾滋病发病机制中起着关键作用。本综述总结了HIV-1黏膜传播生物学研究的最新进展，强调了这些研究在开发预防HIV-1传播的杀微生物剂方面的意义。
使用改进培养模型对HIV-1初始感染进行的新研究更新了目前对黏膜传播的认识。机制研究增进了我们对HIV-1在包括树突状细胞、CD4(+)T细胞和巨噬细胞在内的主要靶细胞介导下的细胞间传播的理解。越来越多的证据表明宿主因素和免疫反应在HIV-1黏膜感染和传播中的重要性。
HIV-1黏膜感染和传播的最新进展丰富了我们对病毒-宿主相互作用和病毒发病机制的认识。对HIV-1与宿主细胞相互作用的功能研究可为设计更有效的抗击HIV-1感染和艾滋病方法提供新见解。
