HIV黏膜传播生物学
Biology of HIV mucosal transmission.
作者信息
Wu Li
机构信息
Department of Microbiology and Molecular Genetics, Medical College of Wisconsin, Milwaukee, WI 53226, USA.
出版信息
Curr Opin HIV AIDS. 2008 Sep;3(5):534-40. doi: 10.1097/COH.0b013e32830634c6.
PURPOSE OF REVIEW
HIV-1 mucosal transmission plays a critical role in HIV-1 infection and AIDS pathogenesis. This review summarizes the latest advances in biological studies of HIV-1 mucosal transmission, highlighting the implications of these studies in the development of microbicides to prevent HIV-1 transmission.
RECENT FINDINGS
New studies of initial HIV-1 infection using improved culture models updated the current view of mucosal transmission. Mechanistic studies enhanced our understanding of cell-cell transmission of HIV-1 mediated by the major target cells, including dendritic cells, CD4(+) T cells, and macrophages. Increasing evidence indicated the significance of host factors and immune responses in HIV-1 mucosal infection and transmission.
SUMMARY
Recent progress in HIV-1 mucosal infection and transmission enriches our knowledge of virus-host interactions and viral pathogenesis. Functional studies of HIV-1 interactions with host cells can provide new insights into the design of more effective approaches to combat HIV-1 infection and AIDS.
综述目的
HIV-1黏膜传播在HIV-1感染和艾滋病发病机制中起着关键作用。本综述总结了HIV-1黏膜传播生物学研究的最新进展，强调了这些研究在开发预防HIV-1传播的杀微生物剂方面的意义。
最新发现
使用改进培养模型对HIV-1初始感染进行的新研究更新了目前对黏膜传播的认识。机制研究增进了我们对HIV-1在包括树突状细胞、CD4(+)T细胞和巨噬细胞在内的主要靶细胞介导下的细胞间传播的理解。越来越多的证据表明宿主因素和免疫反应在HIV-1黏膜感染和传播中的重要性。
总结
HIV-1黏膜感染和传播的最新进展丰富了我们对病毒-宿主相互作用和病毒发病机制的认识。对HIV-1与宿主细胞相互作用的功能研究可为设计更有效的抗击HIV-1感染和艾滋病方法提供新见解。
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