Vignola A, Guzzo A, Calvo A, Moglia C, Pessia A, Cavallo E, Cammarosano S, Giacone S, Ghiglione P, Chiò A
Department of Neuroscience, ALS Center, University of Torino, Torino, Italy.
Eur J Neurol. 2008 Nov;15(11):1231-6. doi: 10.1111/j.1468-1331.2008.02303.x. Epub 2008 Sep 18.
Although depression has been widely studied in amyotrophic lateral sclerosis (ALS), there is little information on anxiety.
To detect anxiety in patients with ALS and their caregivers, comparing the diagnostic and the follow-up phases of the disease and assessing its impact on quality of life (QoL).
Anxiety has been evaluated with the State and Trait Anxiety Inventory in a series of 75 consecutive ALS patients and their primary caregivers. Anxiety has been related to depression, QoL, and satisfaction with life.
In patients, state anxiety was significantly higher during the diagnostic phase, whilst in caregivers it was similar in the two phases. Patients' state anxiety was related to depression, shorter disease duration and lower satisfaction with life. Caregivers' state anxiety was related to their trait anxiety. Whilst in patients QoL and satisfaction with life were similar in the two phases, in caregivers there was a significant decrease of satisfaction with life in the follow-up phase.
Treating neurologists should recognize that the diagnostic phase and the earlier period after the diagnosis is characterized by a high level of anxiety both in ALS patients and in their caregivers, and should propose pharmacological and psychological interventions to relieve this highly distressing disturbance.
尽管抑郁症在肌萎缩侧索硬化症（ALS）中已得到广泛研究，但关于焦虑症的信息却很少。
检测ALS患者及其照料者的焦虑情况，比较疾病的诊断阶段和随访阶段，并评估其对生活质量（QoL）的影响。
使用状态-特质焦虑量表对连续75例ALS患者及其主要照料者进行焦虑评估。焦虑与抑郁、生活质量和生活满意度相关。
在患者中，诊断阶段的状态焦虑显著更高，而在照料者中，两个阶段的状态焦虑相似。患者的状态焦虑与抑郁、疾病持续时间较短和生活满意度较低有关。照料者的状态焦虑与他们的特质焦虑有关。虽然患者的生活质量和生活满意度在两个阶段相似，但照料者在随访阶段的生活满意度显著下降。
治疗神经科医生应认识到，在ALS患者及其照料者中，诊断阶段和诊断后的早期阶段都存在高度焦虑，应提出药物和心理干预措施来缓解这种高度痛苦的困扰。
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