蛔虫幼虫阶段对人体血液凝固的体外影响。

In vitro effect of larval stages of Ascaris lumbricoides on human blood clotting.

作者信息

Malla N, Sofi B A, Ganguly N K, Mahajan R C

机构信息

Department of Parasitology, Postgraduate Institute of Medical Education and Research, Chandigarh, India.

出版信息

J Helminthol. 1991 Jun;65(2):133-40. doi: 10.1017/s0022149x00010592.

DOI:10.1017/s0022149x00010592

PMID:1880387

Abstract

The effects of larval stages of Ascaris lumbricoides on human blood clotting was studied in vitro. Extracts and excretory/secretory products of third-stage larvae (L3) and late third-stage larvae (LL3) cultured from ova obtained from infected patients were analysed for anti-coagulant activity. Prothrombin time (PT) was prolonged by the addition of either whole extract of L3/LL3 or ES products of L3/LL3 as compared to controls. Partial thromboplastin time with kaolin (PTTK) was also prolonged on the addition of either extracts of ES products of L3/LL3. The prolongation of PTTK was significantly higher with extracts/ES products of L3 when compared to the extracts/ES products of LL3 (p less than 0.005). Thrombin time (TT) was prolonged by extracts of L3/LL3 and their ES products.

摘要

在体外研究了蛔虫幼虫阶段对人体血液凝固的影响。对从感染患者获得的虫卵培养出的第三期幼虫（L3）和晚期第三期幼虫（LL3）的提取物以及排泄/分泌产物进行了抗凝血活性分析。与对照组相比，添加L3/LL3的全提取物或L3/LL3的ES产物可延长凝血酶原时间（PT）。添加L3/LL3的提取物或ES产物后，高岭土部分凝血活酶时间（PTTK）也会延长。与LL3的提取物/ES产物相比，L3的提取物/ES产物使PTTK延长的幅度显著更高（p小于0.005）。L3/LL3的提取物及其ES产物可延长凝血酶时间（TT）。