Bumann Dirk
Infection Biology, Biozentrum, University of Basel, Klingelbergstr. 50/70, CH-4056 Basel, Switzerland.
Curr Opin Microbiol. 2008 Oct;11(5):387-92. doi: 10.1016/j.mib.2008.08.002. Epub 2008 Oct 6.
Novel antimicrobial targets are urgently needed to overcome rising antibiotic resistance of important human pathogens. However, evidence from previous antimicrobial screenings, in silico analysis, and experimental target evaluation suggests that the number of novel bacterial broad-spectrum targets might be severely limited. This is because of the poor conservation of genes among diverse bacterial pathogens, partial functional redundancy and nutrient-rich host environments. Remaining opportunities under these circumstances include the development of narrow-spectrum antibiotics against specific pathogens and the exploration of target combinations.
迫切需要新的抗菌靶点来克服重要人类病原体不断上升的抗生素耐药性。然而，以往抗菌筛选、计算机分析和实验靶点评估的证据表明，新型细菌广谱靶点的数量可能受到严重限制。这是由于不同细菌病原体之间基因保守性差、部分功能冗余以及宿主营养丰富的环境所致。在这种情况下，剩下的机会包括开发针对特定病原体的窄谱抗生素以及探索靶点组合。
