Muraoka H, Sata M, Hino T, Ide T, Noguchi S, Tokeshi S, Yano Y, Ono K, Atono Y, Suzuki H
Second Department of Medicine, Kurume University School of Medicine.
Kansenshogaku Zasshi. 1991 May;65(5):597-603. doi: 10.11150/kansenshogakuzasshi1970.65.597.
We had 11 patients with rubella infection accompanied by hepatic dysfunction from 1979 through 1989. The elevations of sGOT were moderate, but sLDH levels were high. Extra hepatic manifestations were suspected by analysis of LDH isozymes. In 9 out of 11 patients, the sGPT levels returned to normal within 8 weeks. But prolonged courses of abnormal transaminase levels were observed in 2 patients. One was accompanied by underlying chronic hepatitis type non-A, non-B, and the other was supposed to have a prolonged rubella infection. Liver biopsy specimen taken from one patient in the acute phase demonstrated a non-specific reactive hepatitis. These observations suggest that rubella infection should be taken into consideration in making the diagnosis of sporadic hepatitis type non-A, non-B.
1979年至1989年期间，我们收治了11例风疹感染伴肝功能障碍的患者。血清谷草转氨酶（sGOT）升高程度中等，但血清乳酸脱氢酶（sLDH）水平较高。通过乳酸脱氢酶同工酶分析怀疑有肝外表现。11例患者中有9例的血清谷丙转氨酶（sGPT）水平在8周内恢复正常。但有2例患者出现转氨酶水平异常的病程延长。其中1例伴有潜在的非甲非乙型慢性肝炎，另1例推测为风疹感染病程延长。急性期从1例患者获取的肝活检标本显示为非特异性反应性肝炎。这些观察结果表明，在诊断散发性非甲非乙型肝炎时应考虑风疹感染。
