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GPR12 selections of the metabolites from an endophytic Streptomyces sp. associated with Cistanches deserticola.

作者信息

Lin Zhen-Jian, Lu Xiao-Ming, Zhu Tian-Jiao, Fang Yu-Chun, Gu Qian-Qun, Zhu Weiming

机构信息

Key laboratory of Marine Drugs, Chinese Ministry of Education, Qingdao, 266003, People's Republic of China.

出版信息

Arch Pharm Res. 2008 Sep;31(9):1108-14. doi: 10.1007/s12272-001-1276-4. Epub 2008 Sep 20.

DOI:10.1007/s12272-001-1276-4
PMID:18806952
Abstract

An endophytic Streptomyces sp. (AC-2) was isolated from the root of Cistanches deserticola Y.C.Ma.. Chemical investigations of the culture broth of AC-2 afforded fifteen compounds including K1115 A (1), tyrosol (2), phenylethylamine derivatives (3, 4), cyclic dipeptides (5-8), nucleosides and their aglycones (9-13), N-acetyltryptamine (14), and pyrrole-2-carboxylic acid (15). Only tyrosol can promote an increase of intracellular cAMP special on GPR12 transfected cells, such as CHO and HEK293, which means it may be a possible ligand for GPR12.

摘要

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