Tshikalange T E, Meyer J J M, Lall N, Muñoz E, Sancho R, Van de Venter M, Oosthuizen V
Department of Plant Science, University of Pretoria, Pretoria 0002, South Africa.
J Ethnopharmacol. 2008 Oct 28;119(3):478-81. doi: 10.1016/j.jep.2008.08.027. Epub 2008 Sep 2.
[corrected The plants selected in this study are used traditionally in the treatment of sexually transmitted diseases and traditional healers interviewed claimed these plants can also help AIDS patients.
To evaluating the in vitro anti-HIV properties of selected plants in various bioassays.
The extracts were evaluated for their inhibition against alpha-glycohydrolase, reverse transcriptase and viral proteins (NF-kappaB and Tat) which play a significant role in the HIV life cycle.
Terminalia sericea extract (IC(50)=92mg/ml) exhibited a considerable alpha-glucosidase inhibitory activity which was better than acarbose (IC(50)=131mg/ml) under our assay conditions. In the reverse transcriptase assay, T. sericea also showed good inhibitory activity (IC(50)=43mg/ml), which was higher than that of the reference drug, Adriamycin (IC(50)=100mg/ml). The ethyl acetate extract of Elaeodendron transvaalense exhibited the most potent inhibitory activity in both the NF-kappaB and Tat assays with inhibitory activity of 76% and 75% respectively at a concentration of 15mg/ml. The acetone and chloroform extracts of E. transvaalense and Zanthoxylum davyi also showed good activity in the NF-kappaB and Tat assays.
[已修正] 本研究中所选的植物在传统上用于治疗性传播疾病，接受采访的传统治疗师称这些植物也有助于艾滋病患者。
在各种生物测定中评估所选植物的体外抗HIV特性。
评估提取物对α-糖苷水解酶、逆转录酶和病毒蛋白（核因子κB和反式激活因子）的抑制作用，这些在HIV生命周期中起重要作用。
在我们的测定条件下，绢毛榄仁提取物（IC50 = 92mg/ml）表现出相当可观的α-葡萄糖苷酶抑制活性，优于阿卡波糖（IC50 = 131mg/ml）。在逆转录酶测定中，绢毛榄仁也显示出良好的抑制活性（IC50 = 43mg/ml），高于参考药物阿霉素（IC50 = 100mg/ml）。德兰士瓦省象耳豆的乙酸乙酯提取物在核因子κB和反式激活因子测定中均表现出最有效的抑制活性，在浓度为15mg/ml时抑制活性分别为76%和75%。德兰士瓦省象耳豆和大叶花椒的丙酮和氯仿提取物在核因子κB和反式激活因子测定中也表现出良好的活性。
