Takemura K, Obara T, Okano S, Yokota K, Ura H, Saitoh Y, Koike Y, Okamura K, Namiki M
Third Department of Internal Medicine, Asahikawa Medical College, Japan.
Nihon Shokakibyo Gakkai Zasshi. 1991 May;88(5):1177-83.
The expression of epidermal growth factor receptor (EGFR) was studied immunohistochemically in 92 colorectal carcinomas: 21 early and 71 advanced. EGFR immunoreactivity was detected in 15 cases (16.3%) of colorectal carcinomas. All EGFR-positive cases was advanced carcinomas, while no EGFR immunoreactivity was found in early carcinomas. EGFR-positive cases were macroscopically 3.4 type and more than 2 cm in diameter. No significant correlation of EGFR expression with tumor location, stage, lymph node metastasis, degree of differentiation, and prognosis was found. All EGFR-positive cases was synchronous positive for the expression of EGF. These results suggest that EGFR may play an important role in tumor progression in cooperation with EGF.
采用免疫组织化学方法对92例结直肠癌（21例早期癌和71例进展期癌）进行了表皮生长因子受体（EGFR）表达情况的研究。在15例（16.3%）结直肠癌中检测到EGFR免疫反应性。所有EGFR阳性病例均为进展期癌，而早期癌中未发现EGFR免疫反应性。EGFR阳性病例在大体上为3.4型，直径超过2 cm。未发现EGFR表达与肿瘤位置、分期、淋巴结转移、分化程度及预后有显著相关性。所有EGFR阳性病例的表皮生长因子（EGF）表达均呈同步阳性。这些结果提示，EGFR可能与EGF协同在肿瘤进展中发挥重要作用。
