Adhvaryu S G, Dave B J, Trivedi A H
Department of Cancer Biology, Gujarat Cancer and Research Institute, Ahmedabad, India.
Mutat Res. 1991 Sep;261(1):41-9. doi: 10.1016/0165-1218(91)90096-5.
Three cytogenetic endpoints were studied in non-chewing healthy controls and 3 groups of tobacco-areca nut chewers, viz. normal chewers, chewers with oral submucous fibrosis and chewers with oral cancer. Frequencies of sister-chromatid exchanges and chromosome aberrations in peripheral blood lymphocytes and of micronucleated cells in exfoliated buccal mucosa were evaluated. All the parameters showed statistically significant elevations in all 3 groups of chewers compared to the controls. The data indicate possible application of the parameters as sensitive endpoints for monitoring tobacco-areca nut chewers, the group of individuals at higher risk of developing oral cancer, the commonest cancer among Indian males.
在不咀嚼的健康对照者以及三组咀嚼烟草-槟榔的人群（即正常咀嚼者、口腔黏膜下纤维化咀嚼者和口腔癌咀嚼者）中研究了三个细胞遗传学终点。评估了外周血淋巴细胞中的姐妹染色单体交换频率和染色体畸变频率以及脱落颊黏膜中的微核细胞频率。与对照组相比，所有参数在三组咀嚼者中均显示出统计学上的显著升高。数据表明这些参数可能适用于作为监测咀嚼烟草-槟榔人群的敏感终点，这一人群是患口腔癌风险较高的群体，口腔癌是印度男性中最常见的癌症。
