Ledford-Kraemer Marlies R
CLOT-ED, Inc., 130 North Rolling Hill Road,Islamorada, FL 33070, USA.
Semin Thromb Hemost. 2008 Jun;34(4):380-8. doi: 10.1055/s-0028-1085481. Epub 2008 Sep 23.
The latest international guidelines for the laboratory diagnosis of lupus anticoagulants (LA) date back to 1995 and are in need of revision. Various patterns of practice and interpretation by clinical laboratories have altered the intent or usage of the criteria and recommendations made at that time. Moreover, various topics in the preexamination phase of LA testing (such as the role of the clinician in test ordering, the impact of direct thrombin inhibitors or oral anticoagulant therapy, and patient biologic variation) need to be considered in future guidelines. In like fashion, examination issues relating to mixing studies will need critical review. Mixing studies have been applied to a variety of low-phospholipid LA screening assays, and no uniformity or standardization exists as to how these test results should be interpreted or if in fact they are suitable for identifying weak lupus anticoagulants.
狼疮抗凝物（LA）实验室诊断的最新国际指南可追溯到1995年，需要修订。临床实验室的各种实践和解释模式已经改变了当时制定的标准和建议的意图或用途。此外，LA检测的分析前阶段的各种主题（如临床医生在检测医嘱中的作用、直接凝血酶抑制剂或口服抗凝治疗的影响以及患者生物学变异）需要在未来的指南中加以考虑。同样，与混合试验相关的检测问题也需要严格审查。混合试验已应用于多种低磷脂LA筛查试验，对于这些试验结果应如何解释或它们实际上是否适用于识别弱狼疮抗凝物，不存在统一或标准化的方法。
