Siller-Matula J M, Jilma B
Department of Clinical Pharmacology, Medical University of Vienna, Währinger Gürtel 18-20, A-1090 Vienna, Austria.
Food Chem Toxicol. 2008 Nov;46(11):3550-2. doi: 10.1016/j.fct.2008.08.033. Epub 2008 Sep 7.
We investigated if long-lasting (5 h) anaesthesia with isoflurane has different pharmacological effects in two different rat strains: Wistar and Sprague Dawley. The mean blood pressure was 34% higher in Sprague Dawley rats as compared to the Wistar rats (p = 0.04). In Wistar rats, the pH value decreased to 7.1, lactate increased by 53%, creatinine increased 2.7-fold, alanine amino transferase and aspartate amino transferase increased more than 4-fold and lactate dehydrogenase increased 9-fold (p < 0.05). There were no changes in laboratory parameters in Sprague Dawley rats. This indicates that the Wistar rats were more sensitive to a 5 h anaesthesia with isoflurane after a premedication with ketamin/xylazine in the described study design.
我们研究了在两种不同的大鼠品系（Wistar和Sprague Dawley）中，异氟烷持续5小时麻醉是否具有不同的药理作用。与Wistar大鼠相比，Sprague Dawley大鼠的平均血压高34%（p = 0.04）。在Wistar大鼠中，pH值降至7.1，乳酸增加53%，肌酐增加2.7倍，丙氨酸氨基转移酶和天冬氨酸氨基转移酶增加超过4倍，乳酸脱氢酶增加9倍（p < 0.05）。Sprague Dawley大鼠的实验室参数没有变化。这表明在所描述的研究设计中，经氯胺酮/甲苯噻嗪预处理后，Wistar大鼠对异氟烷5小时麻醉更为敏感。
