Schroeck Florian R, Donatucci Craig F, Smathers Emily C, Sun Leon, Albala David M, Polascik Thomas J, Moul Judd W, Krupski Tracey L
Duke Prostate Center, Division of Urology, Department of Surgery, Duke University Medical Center, Durham, North Carolina, USA.
Cancer. 2008 Nov 15;113(10):2687-94. doi: 10.1002/cncr.23887.
Both the 5-item short version of the International Index of Erectile Function (IIEF-5) and the Expanded Prostate Cancer Index Composite (EPIC) have been used to assess erectile function. In this study, the authors compared various definitions of potency according to the IIEF-5 and the EPIC.
Patients with prostate cancer who had completed the IIEF-5 and the EPIC within 7 days of each other were included. The Spearman correlation coefficient (rho) was calculated to assess the relation between IIEF-5 and EPIC sexual domain scores. Concordance of potency rates by IIEF-5 and EPIC was assessed in cross-tabulations. By calculating the area under the receiver operator characteristics (ROC) curve (AUC), the authors ascertained the discriminative ability of the IIEF-5 score to identify potent men as defined by the EPIC.
Analyzing 102 questionnaire pairs, IIEF-5 and EPIC domain scores were found to be highly correlated (rho = 0.776). EPIC sexual domain scores > or =60 had high concordance with IIEF-5 scores > or =17 (98%) and with nearly all single-item definitions of potency (> or =71%). However, an EPIC sexual domain score > or =80 was a very strict definition of potency, and only 54% of patients with IIEF-5 scores > or =22 met this threshold. On the basis of ROC analysis (AUC = 0.90), an IIEF-5 score > or =20 was identified as the ideal cutoff for defining potency and corresponded with an EPIC sexual domain score > or =60.
IIEF-5 and EPIC scores were highly correlated, but potency rates varied widely, depending on the definition of potency. The current results help with the interpretation of sexual function outcomes data in patients with prostate cancer.
国际勃起功能指数5项简短版（IIEF-5）和扩展前列腺癌指数综合量表（EPIC）均已用于评估勃起功能。在本研究中，作者根据IIEF-5和EPIC比较了不同的性功能定义。
纳入在7天内先后完成IIEF-5和EPIC的前列腺癌患者。计算Spearman相关系数（rho）以评估IIEF-5与EPIC性领域得分之间的关系。通过交叉表评估IIEF-5和EPIC性功能正常率的一致性。通过计算受试者操作特征（ROC）曲线下面积（AUC），作者确定IIEF-5评分识别EPIC定义的性功能正常男性的鉴别能力。
分析102对问卷，发现IIEF-5与EPIC领域得分高度相关（rho = 0.776）。EPIC性领域得分≥60与IIEF-5得分≥17高度一致（98%），与几乎所有单项性功能正常定义也高度一致（≥71%）。然而，EPIC性领域得分≥80是一个非常严格的性功能正常定义，只有54%的IIEF-5得分≥22的患者达到该阈值。基于ROC分析（AUC = 0.90），IIEF-5得分≥20被确定为定义性功能正常的理想临界值，对应于EPIC性领域得分≥60。
IIEF-5和EPIC得分高度相关，但性功能正常率因性功能正常的定义不同而有很大差异。目前的结果有助于解释前列腺癌患者的性功能结果数据。
