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本文引用的文献

1
Occurrence, seasonality and genetic diversity of Vibrio vulnificus in coastal seaweeds and water along the Kii Channel, Japan.日本纪伊水道沿岸海藻和水体中创伤弧菌的发生、季节性及遗传多样性
FEMS Microbiol Ecol. 2008 May;64(2):209-18. doi: 10.1111/j.1574-6941.2008.00460.x. Epub 2008 Mar 18.
2
Further characterization of Vibrio vulnificus rugose variants and identification of a capsular and rugose exopolysaccharide gene cluster.创伤弧菌粗糙变体的进一步特征分析及荚膜和粗糙胞外多糖基因簇的鉴定
Infect Immun. 2008 Apr;76(4):1485-97. doi: 10.1128/IAI.01289-07. Epub 2008 Jan 22.
3
The post-transcriptional regulator CsrA plays a central role in the adaptation of bacterial pathogens to different stages of infection in animal hosts.转录后调节因子CsrA在细菌病原体适应动物宿主感染的不同阶段中起着核心作用。
Microbiology (Reading). 2008 Jan;154(Pt 1):16-29. doi: 10.1099/mic.0.2007/012286-0.
4
Identification and functional analysis of vibrio vulnificus SmcR, a novel global regulator.创伤弧菌新型全局调控因子SmcR的鉴定与功能分析
J Microbiol Biotechnol. 2007 Feb;17(2):325-34.
5
Population structures of two genotypes of Vibrio vulnificus in oysters (Crassostrea virginica) and seawater.牡蛎（弗吉尼亚巨蛎）和海水中两种创伤弧菌基因型的种群结构
Appl Environ Microbiol. 2008 Jan;74(1):80-5. doi: 10.1128/AEM.01434-07. Epub 2007 Nov 9.
6
The role of quorum sensing and the effect of environmental conditions on biofilm formation by strains of Vibrio vulnificus.群体感应的作用以及环境条件对创伤弧菌菌株生物膜形成的影响。
Biofouling. 2006;22(3-4):133-44. doi: 10.1080/08927010600691879.
7
Capsular polysaccharide phase variation in Vibrio vulnificus.创伤弧菌的荚膜多糖相变
Appl Environ Microbiol. 2006 Nov;72(11):6986-93. doi: 10.1128/AEM.00544-06. Epub 2006 Aug 25.
8
CsrA post-transcriptionally represses pgaABCD, responsible for synthesis of a biofilm polysaccharide adhesin of Escherichia coli.CsrA在转录后抑制pgaABCD，pgaABCD负责大肠杆菌生物膜多糖粘附素的合成。
Mol Microbiol. 2005 Jun;56(6):1648-63. doi: 10.1111/j.1365-2958.2005.04648.x.
9
A rapid and simple PCR analysis indicates there are two subgroups of Vibrio vulnificus which correlate with clinical or environmental isolation.一项快速且简单的聚合酶链反应（PCR）分析表明，创伤弧菌存在两个亚群，这与临床或环境分离情况相关。
Microbiol Immunol. 2005;49(4):381-9. doi: 10.1111/j.1348-0421.2005.tb03731.x.
10
High-frequency phase variation of Vibrio vulnificus 1003: isolation and characterization of a rugose phenotypic variant.创伤弧菌1003的高频相变：一种皱缩表型变体的分离与鉴定
J Bacteriol. 2005 Apr;187(7):2519-25. doi: 10.1128/JB.187.7.2519-2525.2005.

CsrA抑制创伤弧菌生物膜的形成。

csrA inhibits the formation of biofilms by Vibrio vulnificus.

作者信息

Jones Melissa K, Warner Elizabeth B, Oliver James D

机构信息

Department of Biology, University of North Carolina at Charlotte, Charlotte, NC 28223, USA.

出版信息

Appl Environ Microbiol. 2008 Nov;74(22):7064-6. doi: 10.1128/AEM.01810-08. Epub 2008 Sep 26.

DOI:10.1128/AEM.01810-08
PMID:18820071
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2583499/
Abstract

PCR screening of the shellfish-borne pathogen Vibrio vulnificus revealed csrA-negative strains, and these strains formed increased biofilm compared to csrA-positive strains. Complementation in trans with csrA resulted in reduced biofilm formation, similar to that by csrA(+) strains. Our results provide evidence that csrA inhibits biofilm formation in V. vulnificus.

摘要

对食源性病原菌创伤弧菌进行的聚合酶链反应（PCR）筛选发现了csrA基因阴性菌株，与csrA基因阳性菌株相比，这些菌株形成的生物膜更多。用csrA基因进行反式互补导致生物膜形成减少，与csrA(+)菌株相似。我们的结果证明，csrA基因抑制创伤弧菌生物膜的形成。