Karaer Abdullah, Karaer Kadri, Ozaksit Gulnur, Ceylaner Serdar, Percin E Ferda
Department of Obstetrics and Gynecology, Dr Zekai Tahir Burak Woman Health Education and Research Hospital, Ankara, Turkey.
Am J Obstet Gynecol. 2008 Dec;199(6):662.e1-5. doi: 10.1016/j.ajog.2008.06.013. Epub 2008 Sep 25.
This study was undertaken to determine the prevalence of Y-chromosome microdeletions in couples with recurrent pregnancy loss (RPL) as compared with fertile couples.
Forty-three men from couples with recurrent pregnancy loss, and 43 men from couples with a live birth and no history of miscarriages were recruited from Zekai Tahir Burak Woman Health, Education and Research Hospital. The DNA was tested for the presence of 4 sequence tagged sites (STSs) spanning 4 AZF regions: DYS220 (AZFb), DYS235, DYS236, and DYS237 (AZFd).
Seven (7) of the 43 men (16%) from couples with recurrent pregnancy loss had microdeletions in 1 or more of the 4 segments studied, whereas none of the fertile men had any microdeletions (P < .05). Their microdeletions were all found specifically at locus DYS 220 (AZFb).
The prevalence of the Y chromosome microdeletion in AZF region was much higher in men from couples with recurrent pregnancy loss than men in fertile couples. This study showed that Y chromosome microdeletion in AZF region may be a possible etiologic factor of recurrent pregnancy loss.
本研究旨在确定复发性流产（RPL）夫妇与可育夫妇相比Y染色体微缺失的患病率。
从泽凯·塔希尔·布拉克妇女健康、教育和研究医院招募了43名来自复发性流产夫妇的男性，以及43名有活产且无流产史夫妇的男性。检测DNA中跨越4个无精子因子（AZF）区域的4个序列标签位点（STS）的存在情况：DYS220（AZFb）、DYS235、DYS236和DYS237（AZFd）。
43名来自复发性流产夫妇的男性中有7名（16%）在研究的4个片段中的1个或多个片段存在微缺失，而可育男性中无一例有微缺失（P <.05）。他们的微缺失均特异性地出现在位点DYS 220（AZFb）。
复发性流产夫妇中男性的AZF区域Y染色体微缺失患病率远高于可育夫妇中的男性。本研究表明，AZF区域的Y染色体微缺失可能是复发性流产的一个可能病因。
