复发性流产病例中的男性因素检测：一项叙述性综述。
Male factor testing in recurrent pregnancy loss cases: A narrative review.
作者信息
Pourmasumi Soheila, Sabeti Parvin, Ghasemi Nasrin
机构信息
Social Determinants of Health Research Center, Rafsanjan University of Medical Sciences, Rafsanjan, Iran.
Clinical Research Development Unit (CRDU), Moradi Hospital, Rafsanjan University of Medical Sciences, Rafsanjan, Iran.
出版信息
Int J Reprod Biomed. 2022 Jul 6;20(6):447-460. doi: 10.18502/ijrm.v20i6.11440. eCollection 2022 Jun.
Recurrent pregnancy loss is a distinct disorder defined as the loss of at least 2 pregnancies before the 20 wk of gestation. With half of the genome of the embryo belonging to the father, the integrity of the sperm genome is crucial for a successful pregnancy. Semen analysis is recommended for men in such cases to evaluate sperm concentration, morphology, vitality and motility. However, other important sperm parameters such as sperm epigenetics, aneuploidy, Y chromosome microdeletion and chromatin integrity also correlate with successful pregnancy and delivery rate. This article examines the use of different sperm tests and their importance in male partners of women suffering from recurrent pregnancy loss.
复发性流产是一种独特的疾病，定义为妊娠20周前至少发生2次流产。由于胚胎基因组的一半来自父亲，精子基因组的完整性对于成功妊娠至关重要。对于此类情况的男性，建议进行精液分析以评估精子浓度、形态、活力和运动能力。然而，其他重要的精子参数，如精子表观遗传学、非整倍体、Y染色体微缺失和染色质完整性，也与成功妊娠和分娩率相关。本文探讨了不同精子检测方法的应用及其在复发性流产女性男性伴侣中的重要性。
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