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脑钠肽与心房颤动相关无症状脑损伤的程度相关。

Brain natriuretic peptide correlates with the extent of atrial fibrillation-associated silent brain lesions.

作者信息

Gartner Wolfgang, Zierhut Barbara, Mineva Ivelina, Sodeck Gottfried, Leutmezer Fritz, Domanovits Hans, Prayer Daniela, Wolf Florian, Base Wolfgang, Weissel Michael, Wagner Ludwig

机构信息

Medical University Vienna, Department of Medicine III, Austria.

出版信息

Clin Biochem. 2008 Dec;41(18):1434-9. doi: 10.1016/j.clinbiochem.2008.09.096. Epub 2008 Sep 18.

DOI:10.1016/j.clinbiochem.2008.09.096
PMID:18823968
Abstract

OBJECTIVE

Identification of plasma markers indicative for atrial fibrillation-associated silent brain lesions.

DESIGN AND METHODS

  1. Comparative determination of the plasma concentrations of secretagogin, S100B, neuropeptide Y, brain fatty acid binding protein, matrix metalloprotease 9, brain natriuretic peptide, and of D-Dimer in 222 patients with atrial fibrillation and 28 controls by immunoassays. 2. Correlation of the biochemical marker plasma concentration with the extent of silent white matter brain lesions, as determined by the Fazekas score and N-acetylaspartate-spectroscopy.

RESULTS

  1. Plasma concentrations of brain natriuretic peptide, of neuropeptide Y, and of matrix metalloprotease 9 were significantly higher (all with a p<0.05) in patients suffering from atrial fibrillation than in control subjects. 2. Brain natriuretic peptide correlated significantly with the Fazekas score (R=0.41; p<0.005). 3. Brain natriuretic peptide plasma concentrations were significantly higher in patients with a pathological N-acetylaspartate magnetic resonance-spectrometry (p<0.05).

CONCLUSION

Brain natriuretic peptide plasma concentrations correlate with the extent of atrial fibrillation-associated silent brain lesions.

摘要

目的

鉴定可指示房颤相关无症状脑损伤的血浆标志物。

设计与方法

  1. 通过免疫测定法比较222例房颤患者和28例对照者血浆中分泌粒蛋白、S100B、神经肽Y、脑脂肪酸结合蛋白、基质金属蛋白酶9、脑钠肽及D-二聚体的浓度。2. 将生化标志物血浆浓度与由Fazekas评分和N-乙酰天门冬氨酸光谱法测定的无症状脑白质损伤程度进行相关性分析。

结果

  1. 房颤患者血浆中的脑钠肽、神经肽Y和基质金属蛋白酶9浓度显著高于对照组（均p<0.05）。2. 脑钠肽与Fazekas评分显著相关（R=0.41；p<0.005）。3. 病理N-乙酰天门冬氨酸磁共振光谱检查的患者血浆脑钠肽浓度显著更高（p<0.05）。

结论

血浆脑钠肽浓度与房颤相关无症状脑损伤程度相关。

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