Department of Neurology, Wendeng Center Hospital of Weihai, the Affiliated Hospital of Weifang Medical College, Weihai, Shandong 264400, China; E-Mails:
Int J Mol Sci. 2010 Oct 19;11(10):3988-98. doi: 10.3390/ijms11103988.
Lysophosphatidic acid (LPA), which is proposed to play an important role in normal physiological situations such as wound healing, vascular tone, vascular integrity and reproduction, may be involved in the etiology of some diseases such as atherosclerosis, cancer, obesity or myocardial infarction. Abnormal findings, including silent brain infarction (SBI), are frequently observed by magnetic resonance imaging (MRI) in patients with nonvalvular atrial fibrillation (NVAF). However, whether there is a relationship between LPA level and the prevalence of SBI has not been extensively studied. In the present study, the association between them was investigated. 235 patients with NVAF, 116 cases of SBI without NVAF and 120 cases of healthy volunteers (control group), who did not receive any antithrombotic therapy, were enrolled in this study. Plasma LPA levels in the NVAF with SBI group were significantly higher than that in the control group (p < 0.01), NVAF without SBI group (p < 0.01) and SBI without NVAF group (p < 0.01). The LPA levels are lower in the control group than in the NVAF without SBI and SBI without NVAF groups (p < 0.01), however, the latter two groups did not significantly differ from each other for LPA levels (p > 0.05) There were significant differences in the positive rate of platelet activation between each of the groups (p < 0.01). The positive rate of platelet activation was significantly higher in the NVAF with SBI group. We suggest that LPA might be a novel marker for estimation of the status of platelet activation and the risk factor for SBI onset in NVAF patients. We expected that plasma LPA levels could predict the occurrence of SBI in NVAF patients.
溶血磷脂酸（LPA）被认为在正常生理情况下（如伤口愈合、血管张力、血管完整性和生殖）发挥重要作用，可能与某些疾病（如动脉粥样硬化、癌症、肥胖或心肌梗死）的病因有关。在非瓣膜性心房颤动（NVAF）患者中，磁共振成像（MRI）经常观察到异常发现，包括无症状性脑梗死（SBI）。然而，LPA 水平与 SBI 发生率之间是否存在关系尚未得到广泛研究。本研究旨在探讨两者之间的关系。共纳入 235 例 NVAF 患者、116 例无 NVAF 的 SBI 患者和 120 例健康志愿者（对照组），这些患者均未接受任何抗血栓治疗。NVAF 合并 SBI 组的血浆 LPA 水平明显高于对照组（p<0.01）、无 SBI 的 NVAF 组（p<0.01）和无 NVAF 的 SBI 组（p<0.01）。对照组的 LPA 水平低于无 SBI 的 NVAF 组和无 NVAF 的 SBI 组（p<0.01），但后两组之间的 LPA 水平无显著差异（p>0.05）。各组间血小板活化的阳性率存在显著差异（p<0.01）。NVAF 合并 SBI 组血小板活化的阳性率明显更高。我们认为 LPA 可能是评估血小板活化状态和 NVAF 患者 SBI 发病风险的新型标志物。我们期望血浆 LPA 水平可以预测 NVAF 患者 SBI 的发生。
