利用光子晶体波导对蛋白质进行特异性检测。
Specific detection of proteins using photonic crystal waveguides.
作者信息
Buswell S C, Wright V A, Buriak J M, Van V, Evoy S
机构信息
Department of Electrical and Computer Engineering, University of Alberta, Edmonton, Alberta T6G 2V4, Canada.
出版信息
Opt Express. 2008 Sep 29;16(20):15949-57. doi: 10.1364/oe.16.015949.
Specific detection of proteins is demonstrated using planar photonic crystal waveguides. Using immobilized biotin as probe, streptavidin was captured, causing the waveguide mode cut-off to red-shift. The device was shown to detect a 2.5 nm streptavidin film with a 0.86 nm cut-off red-shift. An improved photonic crystal waveguide sensor design is also described and shown to have a 40% improved bulk refractive index response.
利用平面光子晶体波导实现了对蛋白质的特异性检测。以固定化生物素作为探针，捕获链霉亲和素，导致波导模式截止向红移。该装置能够检测到厚度为2.5 nm的链霉亲和素膜，截止红移为0.86 nm。还描述了一种改进的光子晶体波导传感器设计，其体折射率响应提高了40%。
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