Marcinko Darko, Popović-Knapić Vesna, Franić Tomislav, Karlović Dalibor, Martinac Marko, Brataljenović Tomo, Jakovljević Miro
University Psychiatric Clinic Rebro, Clinical Hospital Centre Zagreb, Kispatićeva 12, 10000 Zagreb, Croatia.
Psychiatr Danub. 2008 Sep;20(3):390-5.
Suicidal behavior is a major health risk in schizophrenia. The aim of this study was to evaluate serum cholesterol concentrations and some socio-demographic parameters in suicidal and non-suicidal men suffering from schizophrenia. Results of this study show that there were no differences in socio-demographic parameters between suicidal and non-suicidal schizophrenic patients but there was a difference in the level of cholesterol (lower in suicidal patients). Duration of untreated psychosis was higher in suicidal patients, which could means that suicidality is a process determined by many different factors including time of treatment. Suicidal patients in our study have been more seriously ill than non-suicidal (had higher scores on PANNS and HDRS-17) and we explained these findings by the fact of damage associated to higher time of non-treatment. Our results show that cholesterol has an important role in distinguishing suicidal from non-suicidal patients, which, if confirmed on a higher number of patients and in more studies, may be of considerable clinical significance. Clinical management of suicidal states is based on integrative approach and includes ensuring immediate safety, the use of psychosocial techniques to address depression and psychosocial stressors, and targeted pharmacotherapy for psychotic and depressive symptoms.
自杀行为是精神分裂症中的一项重大健康风险。本研究的目的是评估患有精神分裂症的自杀和非自杀男性的血清胆固醇浓度以及一些社会人口统计学参数。本研究结果表明，自杀和非自杀的精神分裂症患者在社会人口统计学参数上没有差异，但胆固醇水平存在差异（自杀患者较低）。自杀患者未治疗精神病的持续时间更长，这可能意味着自杀倾向是一个由许多不同因素决定的过程，包括治疗时间。在我们的研究中，自杀患者比非自杀患者病情更严重（在阳性和阴性症状量表及17项汉密尔顿抑郁量表上得分更高），我们用与更长未治疗时间相关的损害这一事实来解释这些发现。我们的结果表明，胆固醇在区分自杀和非自杀患者方面具有重要作用，如果在更多患者和更多研究中得到证实，可能具有相当大的临床意义。自杀状态的临床管理基于综合方法，包括确保即时安全、使用心理社会技术来处理抑郁和心理社会压力源，以及针对精神病性和抑郁症状的靶向药物治疗。
