Mensi Rym, Messaoud Amal, Mhallah Ahmed, Azizi Islem, Salah Walid Haj, Douki Wahiba, Najjar Mohamed Fadhel, Gaha Lotfi
Research Laboratory "Vulnerability to Psychotic Disorders LR05ES10", Faculty of Medicine, University of Monastir, 5012 Monastir, Tunisia ; Clinical Biochemistry and Toxicology Laboratory, University Hospital in Monastir, Monastir, Tunisia.
Research Laboratory "Vulnerability to Psychotic Disorders LR05ES10", Faculty of Medicine, University of Monastir, 5012 Monastir, Tunisia ; Department of Psychiatry, University Hospital in Monastir, Monastir, Tunisia.
Ann Gen Psychiatry. 2016 Dec 16;15:36. doi: 10.1186/s12991-016-0123-1. eCollection 2016.
There have been many studies on psychiatric disorders, but very little is known about the biology of suicide with schizophrenia. In the present study, we are looking for a possible connection between altered lipid profile and suicidal behavior in schizophrenic Tunisian patients.
Assay of total cholesterol (TC), high-density lipoprotein cholesterol (HDL-c), low-density lipoprotein cholesterol (LDL-c), and triglycerides (TG) has been done for 126 schizophrenic patients with and without suicide attempts and 131 healthy controls recruited in the University Hospital of Monastir.
TC and LDL-c levels were significantly higher in schizophrenic patients compared to controls. TC was significantly lower in schizophrenic patients with suicide attempt compared to those without suicide attempt. Depending to the sonority of suicide attempt, TC was significantly lower in patients with recent suicide attempt compared to those with lifetime suicide attempt and without suicide attempt ( < 0.001), and no significant differences between TG, LDL-c, and HDL-c were noted.
Results of this study showed that TC levels in schizophrenic patients after a recent suicide attempt are significantly lower than in patients without suicide attempt and with lifetime suicide attempts. TC can be one of biological markers defined suicidal risk for schizophrenic patients.
关于精神疾病已有许多研究，但对于精神分裂症患者自杀的生物学机制却知之甚少。在本研究中，我们正在探寻突尼斯精神分裂症患者脂质谱改变与自杀行为之间可能存在的联系。
对在莫纳斯提尔大学医院招募的126例有或无自杀未遂史的精神分裂症患者以及131名健康对照者进行了总胆固醇（TC）、高密度脂蛋白胆固醇（HDL-c）、低密度脂蛋白胆固醇（LDL-c）和甘油三酯（TG）的检测。
与对照组相比，精神分裂症患者的TC和LDL-c水平显著更高。有自杀未遂史的精神分裂症患者的TC显著低于无自杀未遂史的患者。根据自杀未遂的严重程度，近期有自杀未遂史的患者的TC显著低于有终生自杀未遂史但无近期自杀未遂史的患者（<0.001），且TG、LDL-c和HDL-c之间未观察到显著差异。
本研究结果表明，近期有自杀未遂史的精神分裂症患者的TC水平显著低于无自杀未遂史以及有终生自杀未遂史的患者。TC可能是确定精神分裂症患者自杀风险的生物学标志物之一。
