Marcinko Darko, Pivac Nela, Martinac Marko, Jakovljević Miro, Mihaljević-Peles Alma, Muck-Seler Dorotea
Department of Psychiatry, Clinical Hospital Center Zagreb, Kispatićeva 12, 10000 Zagreb, Croatia.
Psychiatry Res. 2007 Feb 28;150(1):105-8. doi: 10.1016/j.psychres.2006.08.012. Epub 2007 Jan 31.
Suicidal behavior is a major health risk in psychiatric disorders, especially in schizophrenia, wherein up to 10% patients will commit suicide. However, the neurobiology of suicide is still unclear. Suicidality has been related to decreased central serotonergic (5-hydroxytryptamine, 5-HT) function and reduced cholesterol levels. Platelet 5-HT has been used as a peripheral marker of the central serotonergic synaptosomes. The aim of this study was to evaluate serum cholesterol and platelet 5-HT concentrations in suicidal and non-suicidal men in the first episode of psychosis and in healthy male controls. Venous blood samples were collected within 24 h of admission, and serum cholesterol and platelet 5-HT were determined enzymatically and fluorimetrically. Platelet 5-HT and serum cholesterol concentrations were significantly lower in suicidal than in non-suicidal patients in the first episode of psychosis, and also lower than in healthy controls. Our results suggest that lower concentrations of serum cholesterol and platelet 5-HT in patients with a first episode of psychosis might be useful biological markers of suicidality.
自杀行为是精神疾病中的一项重大健康风险，尤其是在精神分裂症中，高达10%的患者会自杀。然而，自杀的神经生物学机制仍不清楚。自杀倾向与中枢5-羟色胺能（5-羟色胺，5-HT）功能降低和胆固醇水平降低有关。血小板5-HT已被用作中枢5-羟色胺能突触体的外周标志物。本研究的目的是评估首次发作精神病的自杀和非自杀男性以及健康男性对照者的血清胆固醇和血小板5-HT浓度。在入院24小时内采集静脉血样本，采用酶法和荧光法测定血清胆固醇和血小板5-HT。首次发作精神病的自杀患者的血小板5-HT和血清胆固醇浓度显著低于非自杀患者，也低于健康对照者。我们的结果表明，首次发作精神病患者血清胆固醇和血小板5-HT浓度较低可能是自杀倾向的有用生物学标志物。
