Gupta Soma, Saha Pradip Kumar, Mukhopadhyay Ashish
Department of Biochemistry, Calcutta National Medical College, Kolkata 700014.
J Indian Med Assoc. 2008 Apr;106(4):240, 242.
The coexistence of hypothroidism and depression is already reported and both of these conditions are known to share some common clinical symptoms. Serum cholesterol level is known to be altered in either condition considered separately. But, no report is obtained regarding serum cholesterol level when both the conditions coexist. In this study, 78 patients (61 females and 17 males, age ranged 19 to 67 years) suffering from major depressive disorder were included. Serum T3, T4, TSH and cholesterol levels were estimated in all of them. Sixty-two patients were found to be euthyroid and 16 patients (11 females, 5 males) were found to be hypothyroid. Among female patients, 6 had subclinical hypothyroidism and 5 had overt hypothyroidism. Among male patients 3 had subclinical hypothyroidism and 2 had overt hypothyroidism. The overall prevalence of hypothyroidism in major depressive disorder was estimated as 20.5%. Mean serum cholesterol level in 62 euthyroid patients was found to be 150.9% +/- 16 mg% and that of 16 hypothyroid patients to be 190.7 +/- 12 mg% showing a significant difference (p < 0.01). Thus estimation of cholesterol in major depressive disorder patients may give an idea regarding their thyroid status and vice-versa.
甲状腺功能减退症与抑郁症并存的情况已有报道，并且已知这两种病症有一些共同的临床症状。单独考虑这两种病症时，血清胆固醇水平都会发生改变。但是，关于这两种病症并存时血清胆固醇水平的情况尚无报道。在本研究中，纳入了78例患有重度抑郁症的患者（61名女性和17名男性，年龄在19至67岁之间）。对所有患者的血清三碘甲状腺原氨酸（T3）、甲状腺素（T4）、促甲状腺激素（TSH）和胆固醇水平进行了测定。发现62例患者甲状腺功能正常，16例患者（11名女性，5名男性）甲状腺功能减退。在女性患者中，6例患有亚临床甲状腺功能减退症，5例患有明显的甲状腺功能减退症。在男性患者中，3例患有亚临床甲状腺功能减退症，2例患有明显的甲状腺功能减退症。重度抑郁症患者中甲状腺功能减退症的总体患病率估计为20.5%。62例甲状腺功能正常患者的平均血清胆固醇水平为150.9%±16mg%，16例甲状腺功能减退患者的平均血清胆固醇水平为190.7±12mg%，差异有统计学意义（p<0.01）。因此，对重度抑郁症患者进行胆固醇测定可能有助于了解其甲状腺状况，反之亦然。
