Dehesh Tania, Mosleh-Shirazi Mohammad Amin, Dehesh Paria
Modeling in Health Research Center, Institute for Futures Studies in Health, Kerman University of Medical Sciences, Kerman, Iran.
Department of Biostatistics and Epidemiology, School of Public Health, Kerman University of Medical Sciences, Kerman, Iran.
BMC Psychiatry. 2025 Jan 20;25(1):54. doi: 10.1186/s12888-025-06490-3.
Depression and anxiety are the main disorders in patients suffering from hypothyroidism. These disorders can lead to increased patient suffering. Since hypothyroidism is one of the most prevalent endocrine diseases, controlling the metabolic variables that increase the severity of anxiety and depression is important. This study aimed to assess the prevalence of anxiety and depression and to identify their associated factors, including metabolic variables, among people with hypothyroidism.
We performed a cross-sectional study of 1,600 patients with hypothyroidism in Kerman, the southern part of Iran. The prevalence of depression and anxiety was estimated using the Beck Depression Inventory and the Hamilton Anxiety questionnaires, respectively. First, univariate logistic regression was performed. Factors whose P-values were smaller than 0.2 in univariate logistic regression were included in multiple logistic regression for confounder adjustments. The analysis was performed using SPSS version 20.
The rates of depression and anxiety were 59% (95% CI: 53.18-62.11) and 63% (95% CI: 58.42-67.22), respectively. Factors found to be independently associated with anxiety were high TSH, high LDL, high TG, high FBS, high TGAb, high TPoAb, high TC, and hypertension. For depression, high TSH, high LDL, high TG, high FBS, high TC, and hypertension were identified. High TGAb and high TPoAb were independently associated with anxiety but not with depression.
Study findings revealed that a large proportion of patients with hypothyroidism suffer from depression and anxiety. This study also identified factors associated with these disorders. Controlling some metabolic variables may decrease the prevalence and severity of these disorders, help patients with better treatment, and improve their quality of life.
抑郁和焦虑是甲状腺功能减退患者的主要病症。这些病症会导致患者痛苦加剧。由于甲状腺功能减退是最常见的内分泌疾病之一，控制那些会加重焦虑和抑郁严重程度的代谢变量非常重要。本研究旨在评估甲状腺功能减退患者中焦虑和抑郁的患病率，并确定其相关因素，包括代谢变量。
我们对伊朗南部克尔曼的1600名甲状腺功能减退患者进行了一项横断面研究。分别使用贝克抑郁量表和汉密尔顿焦虑问卷来评估抑郁和焦虑的患病率。首先，进行单因素逻辑回归分析。在单因素逻辑回归中P值小于0.2的因素纳入多因素逻辑回归以进行混杂因素调整。分析使用SPSS 20版软件进行。
抑郁和焦虑的发生率分别为59%（95%可信区间：53.18 - 62.11）和63%（95%可信区间：58.42 - 67.22）。发现与焦虑独立相关的因素有高促甲状腺激素（TSH）、高低密度脂蛋白（LDL）、高甘油三酯（TG）、高空腹血糖（FBS）、高甲状腺球蛋白抗体（TGAb）、高甲状腺过氧化物酶抗体（TPoAb）、高总胆固醇（TC）和高血压。对于抑郁，确定的因素有高TSH、高LDL、高TG、高FBS、高TC和高血压。高TGAb和高TPoAb与焦虑独立相关，但与抑郁无关。
研究结果显示，很大一部分甲状腺功能减退患者患有抑郁和焦虑。本研究还确定了与这些病症相关的因素。控制一些代谢变量可能会降低这些病症的患病率和严重程度，有助于患者更好地接受治疗，并改善他们的生活质量。
