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[单核细胞增生李斯特菌暴发:有利于细菌存在的途径综述]

[Listeria monocytogenes outbreaks: a review of the routes that favor bacterial presence].

作者信息

Rossi M Laura, Paiva Analía, Tornese Mariela, Chianelli Sabrina, Troncoso Alcides

机构信息

Escuela de Nutrición Cátedra de Microbiología y Parasitología, Facultad de Medicina, Universidad de Buenos Aires, Argentina.

出版信息

Rev Chilena Infectol. 2008 Oct;25(5):328-35. Epub 2008 Oct 1.

Abstract

Listeria monocytogenes is a foodborne pathogen that causes serious invasive illness, mainly in certain well-defined high-risk groups, including immunocompromised patients, pregnant women and neonates. L. monocytogenes primarily causes abortion, septicaemia or infections of the central nervous systems. Listeriosis outbreaks have mostly been linked to consumption of raw milk or cheese made of unpasteurized milk. Previous outbreaks of listeriosis have been linked to a variety of foods especially processed meats (such as hot dogs, deli meats, and páté). The public health importance of listeriosis is not always recognized, particularly since listeriosis is a relatively rare disease compared with other common foodborne illnesses such as salmonellosis or botulism. However, because of its high case fatality rate, listeriosis ranks among the most frequent causes of death due to foodborne illness: second after salmonellosis. Changes in the manner food is produced, distributed and stored have created the potential for widespread outbreaks involving many countries. The pasteurization of raw milk, which destroys L. monocytogenes, does not eliminate later risk of L. monocytogenes contamination in dairy products. Extensive work has been ongoing in many countries during the last decade to prevent outbreaks and decrease the incidence of listeriosis. A marked reduction has occurred in its incidence in some of these countries during the 1990s, suggesting a relationship between preventive measures and reduction on human cases listeriosis.

摘要

单核细胞增生李斯特菌是一种食源性病原体,主要在某些特定的高危人群中引发严重的侵袭性疾病,这些人群包括免疫功能低下的患者、孕妇和新生儿。单核细胞增生李斯特菌主要导致流产、败血症或中枢神经系统感染。李斯特菌病疫情大多与食用生牛奶或由未杀菌牛奶制成的奶酪有关。以往的李斯特菌病疫情还与多种食品有关,尤其是加工肉类(如热狗、熟食肉类和肉酱)。李斯特菌病对公共卫生的重要性并不总是得到认可,特别是因为与其他常见的食源性疾病(如沙门氏菌病或肉毒中毒)相比,李斯特菌病是一种相对罕见的疾病。然而,由于其高病死率,李斯特菌病位列食源性疾病导致死亡的最常见原因之一:仅次于沙门氏菌病,位居第二。食品生产、分销和储存方式的变化增加了涉及许多国家的广泛疫情爆发的可能性。生牛奶的巴氏杀菌法可杀死单核细胞增生李斯特菌,但并不能消除乳制品随后被单核细胞增生李斯特菌污染的风险。在过去十年中,许多国家一直在进行广泛的工作以预防疫情爆发并降低李斯特菌病的发病率。在20世纪90年代,其中一些国家的发病率显著下降,这表明预防措施与人类李斯特菌病病例减少之间存在关联。

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