埃博拉病毒VP30在转录重新起始中的作用。
Role of Ebola virus VP30 in transcription reinitiation.
作者信息
Martínez Miguel J, Biedenkopf Nadine, Volchkova Valentina, Hartlieb Bettina, Alazard-Dany Nathalie, Reynard Olivier, Becker Stephan, Volchkov Viktor
机构信息
INSERM, U758, Filovirus Laboratory, 21 Av. Tony Garnier, 69365 Lyon, Cedex 07, France.
出版信息
J Virol. 2008 Dec;82(24):12569-73. doi: 10.1128/JVI.01395-08. Epub 2008 Oct 1.
Abstract
VP30 is a phosphoprotein essential for the initiation of Ebola virus transcription. In this work, we have studied the effect of mutations in VP30 phosphorylation sites on the ebolavirus replication cycle by using a reverse genetics system. We demonstrate that VP30 is involved in reinitiation of gene transcription and that this activity is affected by mutations at the phosphorylation sites.
摘要
VP30是埃博拉病毒转录起始所必需的一种磷蛋白。在这项研究中，我们利用反向遗传学系统研究了VP30磷酸化位点突变对埃博拉病毒复制周期的影响。我们证明VP30参与基因转录的重新起始，并且这种活性受到磷酸化位点突变的影响。
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